Characterization and Separation of Platinum-Based Antineoplastic Drugs by Zwitterionic Hydrophilic Interaction Liquid Chromatography (HILIC)–Tandem Mass Spectrometry, and Its Application in Surface Wipe Sampling

Characterization and Separation of Platinum-Based Antineoplastic Drugs by Zwitterionic Hydrophilic Interaction Liquid Chromatography (HILIC)–Tandem Mass Spectrometry, and Its Application in Surface Wipe Sampling

Platinum-based antineoplastic drugs (PtADs) are among the most important and used families of chemotherapy drugs, which, even showing severe side effects and being hindered by drug resistance, are not likely to be replaced clinically any time soon. The growing interest in the occupational health com...

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Bibliographic Details
Main Authors: Stefano Dugheri, Nicola Mucci, Enrico Mini, Donato Squillaci, Giorgio Marrubini, Gianluca Bartolucci, Elisabetta Bucaletti, Giovanni Cappelli, Lucia Trevisani, Giulio Arcangeli
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Separations
Subjects:
platinum-based antineoplastic drugs
cisplatin
carboplatin
oxaliplatin
HILIC–Z
liquid chromatography–mass spectrometry
Online Access:https://www.mdpi.com/2297-8739/8/5/69

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