Role of anti-prothrombin in antiphospholipid syndrome
We studied 99 patients with systemic autoimmune disease (5 males, 94 women; mean age 37 year, range 16-72): 28 Primary Antiphospholipid Syndrome, 67 Systemic lupus Erythematosus, 1 Mixed Connective Tissue Disease, 2 Undifferentiated Connective Tissue Disease and 1 Discoid Lupus. Based on the observa...
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doaj-bc0fd92cc89b49439fd65b49b72fbc4d2020-11-24T20:58:38ZengPAGEPress PublicationsReumatismo0048-74492240-26832002-09-0154310.4081/reumatismo.2002.243Role of anti-prothrombin in antiphospholipid syndromeM. CinquiniM. VianelliF. AllegriR. CattaneoG. BalestrieriA. TincaniWe studied 99 patients with systemic autoimmune disease (5 males, 94 women; mean age 37 year, range 16-72): 28 Primary Antiphospholipid Syndrome, 67 Systemic lupus Erythematosus, 1 Mixed Connective Tissue Disease, 2 Undifferentiated Connective Tissue Disease and 1 Discoid Lupus. Based on the observation that native PT shows conformational changes in presence of Ca++ ions and discloses new epitopes available for binding with phospholipids, we performed 3 different methods for the detection of aPT in presence and absence of Ca++, finding a different incidence of specific autoantibodies, associated with clinical features of APS (aPT in presence of Ca++) or non associated (aPT in absence of Ca++). The presence of aPT was significantly associated also with the presence of Lupus Anticoagulant (LAC). The detection of aPT (in presence of Ca++) significantly enhances diagnostic sensibility of APS allowing the identification of a subset of patients (6/99) with clinical features of APS, but with negative LAC, aCL and aβ2-GPI; in fact (limited to thrombotic episodes) the sensibility rises from 56.2% with one test (LAC) to 81.1% with the application of LAC, aCL, aβ2GPI and aPT.https://reumatismo.org/index.php/reuma/article/view/79 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. Cinquini M. Vianelli F. Allegri R. Cattaneo G. Balestrieri A. Tincani |
spellingShingle |
M. Cinquini M. Vianelli F. Allegri R. Cattaneo G. Balestrieri A. Tincani Role of anti-prothrombin in antiphospholipid syndrome Reumatismo |
author_facet |
M. Cinquini M. Vianelli F. Allegri R. Cattaneo G. Balestrieri A. Tincani |
author_sort |
M. Cinquini |
title |
Role of anti-prothrombin in antiphospholipid syndrome |
title_short |
Role of anti-prothrombin in antiphospholipid syndrome |
title_full |
Role of anti-prothrombin in antiphospholipid syndrome |
title_fullStr |
Role of anti-prothrombin in antiphospholipid syndrome |
title_full_unstemmed |
Role of anti-prothrombin in antiphospholipid syndrome |
title_sort |
role of anti-prothrombin in antiphospholipid syndrome |
publisher |
PAGEPress Publications |
series |
Reumatismo |
issn |
0048-7449 2240-2683 |
publishDate |
2002-09-01 |
description |
We studied 99 patients with systemic autoimmune disease (5 males, 94 women; mean age 37 year, range 16-72): 28 Primary Antiphospholipid Syndrome, 67 Systemic lupus Erythematosus, 1 Mixed Connective Tissue Disease, 2 Undifferentiated Connective Tissue Disease and 1 Discoid Lupus. Based on the observation that native PT shows conformational changes in presence of Ca++ ions and discloses new epitopes available for binding with phospholipids, we performed 3 different methods for the detection of aPT in presence and absence of Ca++, finding a different incidence of specific autoantibodies, associated with clinical features of APS (aPT in presence of Ca++) or non associated (aPT in absence of Ca++). The presence of aPT was significantly associated also with the presence of Lupus Anticoagulant (LAC). The detection of aPT (in presence of Ca++) significantly enhances diagnostic sensibility of APS allowing the identification of a subset of patients (6/99) with clinical features of APS, but with negative LAC, aCL and aβ2-GPI; in fact (limited to thrombotic episodes) the sensibility rises from 56.2% with one test (LAC) to 81.1% with the application of LAC, aCL, aβ2GPI and aPT. |
url |
https://reumatismo.org/index.php/reuma/article/view/79 |
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