Brain Protease Activated Receptor 1 Pathway: A Therapeutic Target in the Superoxide Dismutase 1 (SOD1) Mouse Model of Amyotrophic Lateral Sclerosis
Glia cells are involved in upper motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Protease activated receptor 1 (PAR1) pathway is related to brain pathologies. Brain PAR1 is located on peri-synaptic astrocytes, adjacent to pyramidal motor neurons, suggesting possible involvement in...
Main Authors: | Efrat Shavit-Stein, Ihab Abu Rahal, Doron Bushi, Orna Gera, Roni Sharon, Shany G. Gofrit, Lea Pollak, Kate Mindel, Nicola Maggio, Yoel Kloog, Joab Chapman, Amir Dori |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-05-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/10/3419 |
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