An outcome analysis of self-expandable metallic stents in central airway obstruction: a cohort study
<p>Abstract</p> <p>Background</p> <p>Self-expandable metallic stents (SEMSs) have provided satisfactory management of central airway obstruction. However, the long-term benefits and complications of this management modality in patients with benign and malignant obstruct...
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doaj-bc1e88bc2f414e05a438f94b8e78ad2e2020-11-25T00:09:56ZengBMCJournal of Cardiothoracic Surgery1749-80902011-04-01614610.1186/1749-8090-6-46An outcome analysis of self-expandable metallic stents in central airway obstruction: a cohort studyKuo Chih-HsiYu Chih-TengChou Chun-LiangChen Hao-ChengChung Fu-TsaiKuo Han-PinLin Shu-Min<p>Abstract</p> <p>Background</p> <p>Self-expandable metallic stents (SEMSs) have provided satisfactory management of central airway obstruction. However, the long-term benefits and complications of this management modality in patients with benign and malignant obstructing lesions after SEMS placement are unclear. We performed this cohort study to analyze the outcomes of Ultraflex SEMSs in patients with tracheobronchial diseases.</p> <p>Methods</p> <p>Of 149 patients, 72 with benign and 77 with malignant tracheobronchial disease received 211 SEMSs (benign, 116; malignant, 95) and were retrospectively reviewed in a tertiary hospital.</p> <p>Results</p> <p>The baseline characteristics of patients who received SEMS implantation for benign conditions and those who underwent implantation for malignant conditions were significantly different. These characteristics included age (mean, 63.9 vs. 58; <it>p </it>< 0.01), gender (male, 62% vs. 90%; <it>p </it>< 0.0001), smoking (47% vs. 85%; <it>p </it>< 0.0001), forced expiratory volume in 1 second (mean, 0.9 vs. 1.47 L/s; <it>p </it>< 0.0001), follow-up days after SEMS implantation (median; 429 vs. 57; <it>p </it>< 0.0001), and use of covered SEMS (36.2% vs. 94.7%; <it>p </it>< 0.0001). Symptoms improved more after SEMS implantation in patients with benign conditions than in those with malignant conditions (76.7% vs. 51.6%; <it>p </it>< 0.0001). The overall complication rate after SEMS implantation in patients with benign conditions was higher than that in patients with malignancy (42.2% vs. 21.1%; <it>p </it>= 0.001). Successful management of SEMS migration, granulation tissue formation, and SEMS fracture occurred in 100%, 81.25%, and 85% of patients, respectively.</p> <p>Conclusions</p> <p>Patients who received SEMS implantation owing to benign conditions had worse lung function and were older than those who received SEMS for malignancies. There was higher complication rate in patients with benign conditions after a longer follow-up period owing to the nature of the underlying diseases.</p> http://www.cardiothoracicsurgery.org/content/6/1/46 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kuo Chih-Hsi Yu Chih-Teng Chou Chun-Liang Chen Hao-Cheng Chung Fu-Tsai Kuo Han-Pin Lin Shu-Min |
spellingShingle |
Kuo Chih-Hsi Yu Chih-Teng Chou Chun-Liang Chen Hao-Cheng Chung Fu-Tsai Kuo Han-Pin Lin Shu-Min An outcome analysis of self-expandable metallic stents in central airway obstruction: a cohort study Journal of Cardiothoracic Surgery |
author_facet |
Kuo Chih-Hsi Yu Chih-Teng Chou Chun-Liang Chen Hao-Cheng Chung Fu-Tsai Kuo Han-Pin Lin Shu-Min |
author_sort |
Kuo Chih-Hsi |
title |
An outcome analysis of self-expandable metallic stents in central airway obstruction: a cohort study |
title_short |
An outcome analysis of self-expandable metallic stents in central airway obstruction: a cohort study |
title_full |
An outcome analysis of self-expandable metallic stents in central airway obstruction: a cohort study |
title_fullStr |
An outcome analysis of self-expandable metallic stents in central airway obstruction: a cohort study |
title_full_unstemmed |
An outcome analysis of self-expandable metallic stents in central airway obstruction: a cohort study |
title_sort |
outcome analysis of self-expandable metallic stents in central airway obstruction: a cohort study |
publisher |
BMC |
series |
Journal of Cardiothoracic Surgery |
issn |
1749-8090 |
publishDate |
2011-04-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Self-expandable metallic stents (SEMSs) have provided satisfactory management of central airway obstruction. However, the long-term benefits and complications of this management modality in patients with benign and malignant obstructing lesions after SEMS placement are unclear. We performed this cohort study to analyze the outcomes of Ultraflex SEMSs in patients with tracheobronchial diseases.</p> <p>Methods</p> <p>Of 149 patients, 72 with benign and 77 with malignant tracheobronchial disease received 211 SEMSs (benign, 116; malignant, 95) and were retrospectively reviewed in a tertiary hospital.</p> <p>Results</p> <p>The baseline characteristics of patients who received SEMS implantation for benign conditions and those who underwent implantation for malignant conditions were significantly different. These characteristics included age (mean, 63.9 vs. 58; <it>p </it>< 0.01), gender (male, 62% vs. 90%; <it>p </it>< 0.0001), smoking (47% vs. 85%; <it>p </it>< 0.0001), forced expiratory volume in 1 second (mean, 0.9 vs. 1.47 L/s; <it>p </it>< 0.0001), follow-up days after SEMS implantation (median; 429 vs. 57; <it>p </it>< 0.0001), and use of covered SEMS (36.2% vs. 94.7%; <it>p </it>< 0.0001). Symptoms improved more after SEMS implantation in patients with benign conditions than in those with malignant conditions (76.7% vs. 51.6%; <it>p </it>< 0.0001). The overall complication rate after SEMS implantation in patients with benign conditions was higher than that in patients with malignancy (42.2% vs. 21.1%; <it>p </it>= 0.001). Successful management of SEMS migration, granulation tissue formation, and SEMS fracture occurred in 100%, 81.25%, and 85% of patients, respectively.</p> <p>Conclusions</p> <p>Patients who received SEMS implantation owing to benign conditions had worse lung function and were older than those who received SEMS for malignancies. There was higher complication rate in patients with benign conditions after a longer follow-up period owing to the nature of the underlying diseases.</p> |
url |
http://www.cardiothoracicsurgery.org/content/6/1/46 |
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