Long-term Impact of Early-life Stress on Hippocampal Plasticity: Spotlight on Astrocytes
Adverse experiences during childhood are among the most prominent risk factors for developing mood and anxiety disorders later in life. Early-life stress interventions have been established as suitable models to study the neurobiological basis of childhood adversity in rodents. Different models such...
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doaj-bc20e6060afa4a52a3eed59990c5d8662020-11-25T03:43:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-01214999499910.3390/ijms21144999Long-term Impact of Early-life Stress on Hippocampal Plasticity: Spotlight on AstrocytesGürsel Çalışkan0Anke Müller1Anne Albrecht2Institute of Biology, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, GermanyCenter for Behavioral Brain Sciences, 39106 Magdeburg, GermanyCenter for Behavioral Brain Sciences, 39106 Magdeburg, GermanyAdverse experiences during childhood are among the most prominent risk factors for developing mood and anxiety disorders later in life. Early-life stress interventions have been established as suitable models to study the neurobiological basis of childhood adversity in rodents. Different models such as maternal separation, impaired maternal care and juvenile stress during the postweaning/prepubertal life phase are utilized. Especially within the limbic system, they induce lasting alterations in neuronal circuits, neurotransmitter systems, neuronal architecture and plasticity that are further associated with emotional and cognitive information processing. Recent studies found that astrocytes, a special group of glial cells, have altered functions following early-life stress as well. As part of the tripartite synapse, astrocytes interact with neurons in multiple ways by affecting neurotransmitter uptake and metabolism, by providing gliotransmitters and by providing energy to neurons within local circuits. Thus, astrocytes comprise powerful modulators of neuronal plasticity and are well suited to mediate the long-term effects of early-life stress on neuronal circuits. In this review, we will summarize current findings on altered astrocyte function and hippocampal plasticity following early-life stress. Highlighting studies for astrocyte-related plasticity modulation as well as open questions, we will elucidate the potential of astrocytes as new targets for interventions against stress-induced neuropsychiatric disorders.https://www.mdpi.com/1422-0067/21/14/4999astrocyteearly-life stressmaternal separationjuvenile stressdorsal hippocampusventral hippocampus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gürsel Çalışkan Anke Müller Anne Albrecht |
spellingShingle |
Gürsel Çalışkan Anke Müller Anne Albrecht Long-term Impact of Early-life Stress on Hippocampal Plasticity: Spotlight on Astrocytes International Journal of Molecular Sciences astrocyte early-life stress maternal separation juvenile stress dorsal hippocampus ventral hippocampus |
author_facet |
Gürsel Çalışkan Anke Müller Anne Albrecht |
author_sort |
Gürsel Çalışkan |
title |
Long-term Impact of Early-life Stress on Hippocampal Plasticity: Spotlight on Astrocytes |
title_short |
Long-term Impact of Early-life Stress on Hippocampal Plasticity: Spotlight on Astrocytes |
title_full |
Long-term Impact of Early-life Stress on Hippocampal Plasticity: Spotlight on Astrocytes |
title_fullStr |
Long-term Impact of Early-life Stress on Hippocampal Plasticity: Spotlight on Astrocytes |
title_full_unstemmed |
Long-term Impact of Early-life Stress on Hippocampal Plasticity: Spotlight on Astrocytes |
title_sort |
long-term impact of early-life stress on hippocampal plasticity: spotlight on astrocytes |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-07-01 |
description |
Adverse experiences during childhood are among the most prominent risk factors for developing mood and anxiety disorders later in life. Early-life stress interventions have been established as suitable models to study the neurobiological basis of childhood adversity in rodents. Different models such as maternal separation, impaired maternal care and juvenile stress during the postweaning/prepubertal life phase are utilized. Especially within the limbic system, they induce lasting alterations in neuronal circuits, neurotransmitter systems, neuronal architecture and plasticity that are further associated with emotional and cognitive information processing. Recent studies found that astrocytes, a special group of glial cells, have altered functions following early-life stress as well. As part of the tripartite synapse, astrocytes interact with neurons in multiple ways by affecting neurotransmitter uptake and metabolism, by providing gliotransmitters and by providing energy to neurons within local circuits. Thus, astrocytes comprise powerful modulators of neuronal plasticity and are well suited to mediate the long-term effects of early-life stress on neuronal circuits. In this review, we will summarize current findings on altered astrocyte function and hippocampal plasticity following early-life stress. Highlighting studies for astrocyte-related plasticity modulation as well as open questions, we will elucidate the potential of astrocytes as new targets for interventions against stress-induced neuropsychiatric disorders. |
topic |
astrocyte early-life stress maternal separation juvenile stress dorsal hippocampus ventral hippocampus |
url |
https://www.mdpi.com/1422-0067/21/14/4999 |
work_keys_str_mv |
AT gurselcalıskan longtermimpactofearlylifestressonhippocampalplasticityspotlightonastrocytes AT ankemuller longtermimpactofearlylifestressonhippocampalplasticityspotlightonastrocytes AT annealbrecht longtermimpactofearlylifestressonhippocampalplasticityspotlightonastrocytes |
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