Cytotoxic and Pro-Apoptotic Effects of Cassane Diterpenoids from the Seeds of Caesalpinia sappan in Cancer Cells

Cytotoxic and Pro-Apoptotic Effects of Cassane Diterpenoids from the Seeds of Caesalpinia sappan in Cancer Cells

The chemical study on the seeds of Caesalpinia sappan led to the isolation of five new cassane diterpenoids, phanginins R‒T (1–3) and caesalsappanins M and N (4 and 5), together with seven known compounds 6–12. Their structures were elucidated on the basis of NMR and HRESIMS analyses. The absolute c...

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Bibliographic Details
Main Authors: Han Bao, Le-Le Zhang, Qian-Yu Liu, Lu Feng, Yang Ye, Jin-Jian Lu, Li-Gen Lin
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Molecules
Subjects:
Caesalpinia sappan
cassane diterpenoids
cytotoxicity
apoptosis
p53
Online Access:http://www.mdpi.com/1420-3049/21/6/791

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