Glioma in Schizophrenia: Is the Risk Higher or Lower?
Whether persons with schizophrenia have a higher or lower incidence of cancer has been discussed for a long time. Due to the complex mechanisms and characteristics of different types of cancer, it is difficult to evaluate the exact relationship between cancers and schizophrenia without considering t...
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doaj-bc2de6921dd14c96ab36b36d4f2c2f702020-11-24T22:05:49ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-09-011210.3389/fncel.2018.00289399589Glioma in Schizophrenia: Is the Risk Higher or Lower?Xingchun Gao0Xingchun Gao1Yajing Mi2Na Guo3Hao Xu4Hao Xu5Pengtao Jiang6Ruisan Zhang7Lixian Xu8Lixian Xu9Xingchun Gou10Shaanxi Key Laboratory of Brain Disorders & Institute of Basic Medical Sciences & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaState Key Laboratory of Military Stomatology, Department of Anesthesiology, School of Stomatology, The Fourth Military Medical University, Xi’an, ChinaShaanxi Key Laboratory of Brain Disorders & Institute of Basic Medical Sciences & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaShaanxi Key Laboratory of Brain Disorders & Institute of Basic Medical Sciences & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaShaanxi Key Laboratory of Brain Disorders & Institute of Basic Medical Sciences & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaState Key Laboratory of Military Stomatology, Department of Anesthesiology, School of Stomatology, The Fourth Military Medical University, Xi’an, ChinaShaanxi Key Laboratory of Brain Disorders & Institute of Basic Medical Sciences & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaShaanxi Key Laboratory of Brain Disorders & Institute of Basic Medical Sciences & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaShaanxi Key Laboratory of Brain Disorders & Institute of Basic Medical Sciences & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaState Key Laboratory of Military Stomatology, Department of Anesthesiology, School of Stomatology, The Fourth Military Medical University, Xi’an, ChinaShaanxi Key Laboratory of Brain Disorders & Institute of Basic Medical Sciences & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, ChinaWhether persons with schizophrenia have a higher or lower incidence of cancer has been discussed for a long time. Due to the complex mechanisms and characteristics of different types of cancer, it is difficult to evaluate the exact relationship between cancers and schizophrenia without considering the type of tumor. Schizophrenia, a disabling mental illness that is now recognized as a neurodevelopmental disorder, is more correlated with brain tumors, such as glioma, than other types of tumors. Thus, we mainly focused on the relationship between schizophrenia and glioma morbidity. Glioma tumorigenesis and schizophrenia may share similar mechanisms; gene/pathway disruption would affect neurodevelopment and reduce the risk of glioma. The molecular defects of disrupted-in-schizophrenia-1 (DISC1), P53, brain-derived neurotrophic factor (BDNF) and C-X-C chemokine receptors type 4 (CXCR4) involved in schizophrenia pathogenesis might play opposite roles in glioma development. Many microRNAs (miRNAs) such as miR-183, miR-9, miR-137 and miR-126 expression change may be involved in the cross talk between glioma prevalence and schizophrenia. Finally, antipsychotic drugs may have antitumor effects. All these factors show that persons with schizophrenia have a decreased incidence of glioma; therefore, epidemiological investigation and studies comparing genetic and epigenetic aberrations involved in both of these complex diseases should be performed. These studies can provide more insightful knowledge about glioma and schizophrenia pathophysiology and help to determine the target/strategies for the prevention and treatment of the two diseases.https://www.frontiersin.org/article/10.3389/fncel.2018.00289/fullschizophreniagliomaprotectionDISC1miRNA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xingchun Gao Xingchun Gao Yajing Mi Na Guo Hao Xu Hao Xu Pengtao Jiang Ruisan Zhang Lixian Xu Lixian Xu Xingchun Gou |
spellingShingle |
Xingchun Gao Xingchun Gao Yajing Mi Na Guo Hao Xu Hao Xu Pengtao Jiang Ruisan Zhang Lixian Xu Lixian Xu Xingchun Gou Glioma in Schizophrenia: Is the Risk Higher or Lower? Frontiers in Cellular Neuroscience schizophrenia glioma protection DISC1 miRNA |
author_facet |
Xingchun Gao Xingchun Gao Yajing Mi Na Guo Hao Xu Hao Xu Pengtao Jiang Ruisan Zhang Lixian Xu Lixian Xu Xingchun Gou |
author_sort |
Xingchun Gao |
title |
Glioma in Schizophrenia: Is the Risk Higher or Lower? |
title_short |
Glioma in Schizophrenia: Is the Risk Higher or Lower? |
title_full |
Glioma in Schizophrenia: Is the Risk Higher or Lower? |
title_fullStr |
Glioma in Schizophrenia: Is the Risk Higher or Lower? |
title_full_unstemmed |
Glioma in Schizophrenia: Is the Risk Higher or Lower? |
title_sort |
glioma in schizophrenia: is the risk higher or lower? |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2018-09-01 |
description |
Whether persons with schizophrenia have a higher or lower incidence of cancer has been discussed for a long time. Due to the complex mechanisms and characteristics of different types of cancer, it is difficult to evaluate the exact relationship between cancers and schizophrenia without considering the type of tumor. Schizophrenia, a disabling mental illness that is now recognized as a neurodevelopmental disorder, is more correlated with brain tumors, such as glioma, than other types of tumors. Thus, we mainly focused on the relationship between schizophrenia and glioma morbidity. Glioma tumorigenesis and schizophrenia may share similar mechanisms; gene/pathway disruption would affect neurodevelopment and reduce the risk of glioma. The molecular defects of disrupted-in-schizophrenia-1 (DISC1), P53, brain-derived neurotrophic factor (BDNF) and C-X-C chemokine receptors type 4 (CXCR4) involved in schizophrenia pathogenesis might play opposite roles in glioma development. Many microRNAs (miRNAs) such as miR-183, miR-9, miR-137 and miR-126 expression change may be involved in the cross talk between glioma prevalence and schizophrenia. Finally, antipsychotic drugs may have antitumor effects. All these factors show that persons with schizophrenia have a decreased incidence of glioma; therefore, epidemiological investigation and studies comparing genetic and epigenetic aberrations involved in both of these complex diseases should be performed. These studies can provide more insightful knowledge about glioma and schizophrenia pathophysiology and help to determine the target/strategies for the prevention and treatment of the two diseases. |
topic |
schizophrenia glioma protection DISC1 miRNA |
url |
https://www.frontiersin.org/article/10.3389/fncel.2018.00289/full |
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