Disparate roles of zinc in chemical hypoxia-induced neuronal death

Disparate roles of zinc in chemical hypoxia-induced neuronal death

Accumulating evidence has provided a causative role of zinc (Zn2+) in neuronal death following ischemic brain injury. Using a hypoxia model of primary cultured cortical neurons with hypoxia-inducing chemicals, cobalt chloride (1 mM CoCl2), deferoxamine (3 mM DFX), and sodium azide (2 mM NaN3), we ev...

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Bibliographic Details
Main Authors: Sujeong eKim, Jung-Woo eSeo, Shin Bi eOh, So Hee eKim, Inki eKim, Nayoung eSuh, Joo-Yong eLee
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Iron
Neuroprotection
Brain Injury
Delayed neuronal death
Metal chelation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00001/full

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