SEVERE ADVERSE REACTIONS TO THE IODIC CONTRAST MEDIA AT THE UROGRAPHY

• Main Author: Rade R Babic
• Format: Article
• Language: English
• Published: University in Nis, Faculty of Medicine 2007-01-01
• Series: Acta Medica Medianae
• Subjects: iodic contrast media; adverse reactions; urograph
• Online Access: http://publisher.medfak.ni.ac.rs/2007-html/1-broj/SEVERE%20ADVERSE%20REACTIONS%20TO%20IODINE%20CONTRAST%20MEDIA%20IN%20UROGRAPHY.pdf

During urography (IVU) or any other kind of endographic examination, adverse reactions can develop during or immediately after intravascular application of iodine contrast media (ICM) of which some endanger the patients’ health and life. The aim of the paper was to present adverse reactions of an organism to ICM. That is why the current interest in this problem has imposed to us a necessity to present this study.In the period from January 1994 to December 2005. in a Specialized Department of the Institute of Radiology of the Clinical Centre Nis, 11.885 IVU were done. An urographyc examination was performed with ionic or non ionic ICM of the same concentration (300 mg I/ml) or an approximate to it, in the dosage of 1,0 ml/kg. Before intravenous application (iv), ICM was heated to body temperature. Application of ICM was done through the braunile, as a slow bolus, in the course of 1-1,5 min. In the series of 11.885 urographic examinations, there were severe adverse reactions in 17 patients (0,14% ili 1:699 IVU). There was no fatal outcome. Adverse reactions at our clinic that could have ended up with lethal outcome, with proper and prompt treatment ended with satisfactory results, so they were registered as severe reactions.