Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men
Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospec...
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doaj-bc4c5c30576e4482b21dec054bb7c0e32020-11-25T01:41:51ZengMDPI AGJournal of Clinical Medicine2077-03832020-03-019377310.3390/jcm9030773jcm9030773Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in MenTae Ryom Oh0Hong Sang Choi1Chang Seong Kim2Dong-Ryeol Ryu3Sun-Hee Park4Shin Young Ahn5Soo Wan Kim6Eun Hui Bae7Seong Kwon Ma8Department of Internal Medicine, Chonnam National University Medical School, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju 61469, KoreaDepartment of Internal Medicine, College of Medicine, Ewha Womans University Seoul Hospital, Seoul 07985, KoreaDivision of Nephrology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu 41944, KoreaDepartment of Internal Medicine, Korea University College of Medicine, Seoul 02841, KoreaDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju 61469, KoreaLupus nephritis (LN) is a major complication of systemic lupus erythematosus. Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospectively analyzed 578 patients diagnosed with LN by renal biopsy. We determine the relationship of serum uric acid to progression of LN using Kaplan−Meier survival analyses and Cox proportional hazards models. The primary end point was LN progression defined as the initiation of dialysis or kidney transplantation. Men had higher mean serum uric acid levels than did women. Every 1 mg/dL increase in baseline uric acid level increased the risk of LN progression by 15.1%. The serum uric acid level was an independent risk factor for LN progression in women (hazard ratio [HR], 1.158; confidence interval [CI], 1.018−1.317; <i>p</i> = 0.028) but not in men (HR, 1.499; CI, 0.964−2.331; <i>p</i> = 0.072). Sensitivity analysis involving serum uric acid terciles generated consistent and robust results. Serum uric acid level was an independent risk factor for LN progression in women but not in men.https://www.mdpi.com/2077-0383/9/3/773lupus nephritishyperuricemiauric acidsystemic lupus erythematosusprognosisproportional hazard modelsend stage renal diseasesex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tae Ryom Oh Hong Sang Choi Chang Seong Kim Dong-Ryeol Ryu Sun-Hee Park Shin Young Ahn Soo Wan Kim Eun Hui Bae Seong Kwon Ma |
spellingShingle |
Tae Ryom Oh Hong Sang Choi Chang Seong Kim Dong-Ryeol Ryu Sun-Hee Park Shin Young Ahn Soo Wan Kim Eun Hui Bae Seong Kwon Ma Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men Journal of Clinical Medicine lupus nephritis hyperuricemia uric acid systemic lupus erythematosus prognosis proportional hazard models end stage renal disease sex |
author_facet |
Tae Ryom Oh Hong Sang Choi Chang Seong Kim Dong-Ryeol Ryu Sun-Hee Park Shin Young Ahn Soo Wan Kim Eun Hui Bae Seong Kwon Ma |
author_sort |
Tae Ryom Oh |
title |
Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men |
title_short |
Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men |
title_full |
Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men |
title_fullStr |
Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men |
title_full_unstemmed |
Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men |
title_sort |
serum uric acid is associated with renal prognosis of lupus nephritis in women but not in men |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-03-01 |
description |
Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospectively analyzed 578 patients diagnosed with LN by renal biopsy. We determine the relationship of serum uric acid to progression of LN using Kaplan−Meier survival analyses and Cox proportional hazards models. The primary end point was LN progression defined as the initiation of dialysis or kidney transplantation. Men had higher mean serum uric acid levels than did women. Every 1 mg/dL increase in baseline uric acid level increased the risk of LN progression by 15.1%. The serum uric acid level was an independent risk factor for LN progression in women (hazard ratio [HR], 1.158; confidence interval [CI], 1.018−1.317; <i>p</i> = 0.028) but not in men (HR, 1.499; CI, 0.964−2.331; <i>p</i> = 0.072). Sensitivity analysis involving serum uric acid terciles generated consistent and robust results. Serum uric acid level was an independent risk factor for LN progression in women but not in men. |
topic |
lupus nephritis hyperuricemia uric acid systemic lupus erythematosus prognosis proportional hazard models end stage renal disease sex |
url |
https://www.mdpi.com/2077-0383/9/3/773 |
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