Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men

• Main Authors: Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Dong-Ryeol Ryu, Sun-Hee Park, Shin Young Ahn, Soo Wan Kim, Eun Hui Bae, Seong Kwon Ma
• Format: Article
• Language: English
• Published: MDPI AG 2020-03-01
• Series: Journal of Clinical Medicine
• Subjects: lupus nephritis; hyperuricemia; uric acid; systemic lupus erythematosus; prognosis; proportional hazard models; end stage renal disease; sex
• Online Access: https://www.mdpi.com/2077-0383/9/3/773

Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospectively analyzed 578 patients diagnosed with LN by renal biopsy. We determine the relationship of serum uric acid to progression of LN using Kaplan&#8722;Meier survival analyses and Cox proportional hazards models. The primary end point was LN progression defined as the initiation of dialysis or kidney transplantation. Men had higher mean serum uric acid levels than did women. Every 1 mg/dL increase in baseline uric acid level increased the risk of LN progression by 15.1%. The serum uric acid level was an independent risk factor for LN progression in women (hazard ratio [HR], 1.158; confidence interval [CI], 1.018&#8722;1.317; <i>p</i> = 0.028) but not in men (HR, 1.499; CI, 0.964&#8722;2.331; <i>p</i> = 0.072). Sensitivity analysis involving serum uric acid terciles generated consistent and robust results. Serum uric acid level was an independent risk factor for LN progression in women but not in men.