Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia

Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia

Vascular endothelial growth factor-A (VEGF-A) is best known as a key regulator of the formation of new blood vessels. Neutralization of VEGF-A with anti-VEGF therapy e.g. bevacizumab, can be painful, and this is hypothesized to result from a loss of VEGF-A-mediated neuroprotection. The multiple vegf...

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Bibliographic Details
Main Authors: R.P. Hulse, N. Beazley-Long, J. Hua, H. Kennedy, J. Prager, H. Bevan, Y. Qiu, E.S. Fernandes, M.V. Gammons, K. Ballmer-Hofer, A.C. Gittenberger de Groot, A.J. Churchill, S.J. Harper, S.D. Brain, D.O. Bates, L.F. Donaldson
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Neurobiology of Disease
Subjects:
Vascular endothelial growth factor A
Alternative mRNA splicing
Neuropathy
Nociceptors
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002435

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http://www.sciencedirect.com/science/article/pii/S0969996114002435

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