Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei Strains
New anti-infective agents are urgently needed to fight microbial resistance. Methicillin-resistant Staphylococcus aureus (MRSA) strains are particularly responsible for complicated pathologies that are difficult to treat due to their virulence and the formation of persistent biofilms forming a compl...
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Format: | Article |
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MDPI AG
2019-03-01
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Series: | Molecules |
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Online Access: | http://www.mdpi.com/1420-3049/24/6/1024 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laetitia Bocquet Sevser Sahpaz Natacha Bonneau Claire Beaufay Séverine Mahieux Jennifer Samaillie Vincent Roumy Justine Jacquin Simon Bordage Thierry Hennebelle Feng Chai Joëlle Quetin-Leclercq Christel Neut Céline Rivière |
spellingShingle |
Laetitia Bocquet Sevser Sahpaz Natacha Bonneau Claire Beaufay Séverine Mahieux Jennifer Samaillie Vincent Roumy Justine Jacquin Simon Bordage Thierry Hennebelle Feng Chai Joëlle Quetin-Leclercq Christel Neut Céline Rivière Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei Strains Molecules Humulus lupulus prenylated phenolic compounds antimicrobial agents methicillin-resistant Staphylococcus aureus Leishmania mexicana mexicana Trypanosoma brucei brucei |
author_facet |
Laetitia Bocquet Sevser Sahpaz Natacha Bonneau Claire Beaufay Séverine Mahieux Jennifer Samaillie Vincent Roumy Justine Jacquin Simon Bordage Thierry Hennebelle Feng Chai Joëlle Quetin-Leclercq Christel Neut Céline Rivière |
author_sort |
Laetitia Bocquet |
title |
Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei Strains |
title_short |
Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei Strains |
title_full |
Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei Strains |
title_fullStr |
Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei Strains |
title_full_unstemmed |
Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei Strains |
title_sort |
phenolic compounds from humulus lupulus as natural antimicrobial products: new weapons in the fight against methicillin resistant staphylococcus aureus, leishmania mexicana and trypanosoma brucei strains |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2019-03-01 |
description |
New anti-infective agents are urgently needed to fight microbial resistance. Methicillin-resistant Staphylococcus aureus (MRSA) strains are particularly responsible for complicated pathologies that are difficult to treat due to their virulence and the formation of persistent biofilms forming a complex protecting shell. Parasitic infections caused by Trypanosoma brucei and Leishmania mexicana are also of global concern, because of the mortality due to the low number of safe and effective treatments. Female inflorescences of hop produce specialized metabolites known for their antimicrobial effects but underexploited to fight against drug-resistant microorganisms. In this study, we assessed the antimicrobial potential of phenolic compounds against MRSA clinical isolates, T. brucei and L. mexicana. By fractionation process, we purified the major prenylated chalcones and acylphloroglucinols, which were quantified by UHPLC-UV in different plant parts, showing their higher content in the active flowers extract. Their potent antibacterial action (MIC < 1 µg/mL for the most active compound) was demonstrated against MRSA strains, through kill curves, post-antibiotic effects, anti-biofilm assays and synergy studies with antibiotics. An antiparasitic activity was also shown for some purified compounds, particularly on T. brucei (IC50 < 1 to 11 µg/mL). Their cytotoxic activity was assessed both on cancer and non-cancer human cell lines. |
topic |
Humulus lupulus prenylated phenolic compounds antimicrobial agents methicillin-resistant Staphylococcus aureus Leishmania mexicana mexicana Trypanosoma brucei brucei |
url |
http://www.mdpi.com/1420-3049/24/6/1024 |
work_keys_str_mv |
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doaj-bc57cf66e2ef48cd999b1cd3e791ebf52020-11-25T02:50:44ZengMDPI AGMolecules1420-30492019-03-01246102410.3390/molecules24061024molecules24061024Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei StrainsLaetitia Bocquet0Sevser Sahpaz1Natacha Bonneau2Claire Beaufay3Séverine Mahieux4Jennifer Samaillie5Vincent Roumy6Justine Jacquin7Simon Bordage8Thierry Hennebelle9Feng Chai10Joëlle Quetin-Leclercq11Christel Neut12Céline Rivière13EA 7394—ICV, Charles Viollette Research Institute, SFR Condorcet FR CNRS 3417, Univ. Lille, INRA, ISA-Yncréa, Univ. Artois, University Littoral Côte d’Opale, 3 rue du Professeur Laguesse, 59000 Lille, FranceEA 7394—ICV, Charles Viollette Research Institute, SFR Condorcet FR CNRS 3417, Univ. Lille, INRA, ISA-Yncréa, Univ. Artois, University Littoral Côte d’Opale, 3 rue du Professeur Laguesse, 59000 Lille, FranceEA 7394—ICV, Charles Viollette Research Institute, SFR Condorcet FR CNRS 3417, Univ. Lille, INRA, ISA-Yncréa, Univ. Artois, University Littoral Côte d’Opale, 3 rue du Professeur Laguesse, 59000 Lille, FrancePharmacognosy Research group, Louvain Drug Research Institute, Université Catholique de Louvain, 1200 Brussels, BelgiumU995—LIRIC, Lille Inflammation Research International Center, University Lille, Inserm, CHU Lille, 59000 Lille, FranceEA 7394—ICV, Charles Viollette Research Institute, SFR Condorcet FR CNRS 3417, Univ. Lille, INRA, ISA-Yncréa, Univ. Artois, University Littoral Côte d’Opale, 3 rue du Professeur Laguesse, 59000 Lille, FranceEA 7394—ICV, Charles Viollette Research Institute, SFR Condorcet FR CNRS 3417, Univ. Lille, INRA, ISA-Yncréa, Univ. Artois, University Littoral Côte d’Opale, 3 rue du Professeur Laguesse, 59000 Lille, FranceEA 7394—ICV, Charles Viollette Research Institute, SFR Condorcet FR CNRS 3417, Univ. Lille, INRA, ISA-Yncréa, Univ. Artois, University Littoral Côte d’Opale, 3 rue du Professeur Laguesse, 59000 Lille, FranceEA 7394—ICV, Charles Viollette Research Institute, SFR Condorcet FR CNRS 3417, Univ. Lille, INRA, ISA-Yncréa, Univ. Artois, University Littoral Côte d’Opale, 3 rue du Professeur Laguesse, 59000 Lille, FranceEA 7394—ICV, Charles Viollette Research Institute, SFR Condorcet FR CNRS 3417, Univ. Lille, INRA, ISA-Yncréa, Univ. Artois, University Littoral Côte d’Opale, 3 rue du Professeur Laguesse, 59000 Lille, FranceU1008—Controlled Drug Delivery Systems and Biomaterials, University Lille, Inserm, CHU Lille, 59000 Lille, FrancePharmacognosy Research group, Louvain Drug Research Institute, Université Catholique de Louvain, 1200 Brussels, BelgiumU995—LIRIC, Lille Inflammation Research International Center, University Lille, Inserm, CHU Lille, 59000 Lille, FranceEA 7394—ICV, Charles Viollette Research Institute, SFR Condorcet FR CNRS 3417, Univ. Lille, INRA, ISA-Yncréa, Univ. Artois, University Littoral Côte d’Opale, 3 rue du Professeur Laguesse, 59000 Lille, FranceNew anti-infective agents are urgently needed to fight microbial resistance. Methicillin-resistant Staphylococcus aureus (MRSA) strains are particularly responsible for complicated pathologies that are difficult to treat due to their virulence and the formation of persistent biofilms forming a complex protecting shell. Parasitic infections caused by Trypanosoma brucei and Leishmania mexicana are also of global concern, because of the mortality due to the low number of safe and effective treatments. Female inflorescences of hop produce specialized metabolites known for their antimicrobial effects but underexploited to fight against drug-resistant microorganisms. In this study, we assessed the antimicrobial potential of phenolic compounds against MRSA clinical isolates, T. brucei and L. mexicana. By fractionation process, we purified the major prenylated chalcones and acylphloroglucinols, which were quantified by UHPLC-UV in different plant parts, showing their higher content in the active flowers extract. Their potent antibacterial action (MIC < 1 µg/mL for the most active compound) was demonstrated against MRSA strains, through kill curves, post-antibiotic effects, anti-biofilm assays and synergy studies with antibiotics. An antiparasitic activity was also shown for some purified compounds, particularly on T. brucei (IC50 < 1 to 11 µg/mL). Their cytotoxic activity was assessed both on cancer and non-cancer human cell lines.http://www.mdpi.com/1420-3049/24/6/1024Humulus lupulusprenylated phenolic compoundsantimicrobial agentsmethicillin-resistant Staphylococcus aureusLeishmania mexicana mexicanaTrypanosoma brucei brucei |