New insights into the mechanism of dynein motor regulation by lissencephaly-1
Lissencephaly (‘smooth brain’) is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease – lissencephaly-1 (LIS1) – has been a focus of intense scrutiny since its first identification almost 30 years a...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-07-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/59737 |
id |
doaj-bc58bf1ae8ee4131a4ced3c53e5f56df |
---|---|
record_format |
Article |
spelling |
doaj-bc58bf1ae8ee4131a4ced3c53e5f56df2021-05-05T21:19:41ZengeLife Sciences Publications LtdeLife2050-084X2020-07-01910.7554/eLife.59737New insights into the mechanism of dynein motor regulation by lissencephaly-1Steven M Markus0https://orcid.org/0000-0002-3098-0236Matthew G Marzo1https://orcid.org/0000-0002-2571-6377Richard J McKenney2Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, United StatesDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, United StatesDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, United StatesLissencephaly (‘smooth brain’) is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease – lissencephaly-1 (LIS1) – has been a focus of intense scrutiny since its first identification almost 30 years ago. LIS1 is a critical regulator of the microtubule motor cytoplasmic dynein, which transports numerous cargoes throughout the cell, and is a key effector of nuclear and neuronal transport during brain development. Here, we review the role of LIS1 in cellular dynein function and discuss recent key findings that have revealed a new mechanism by which this molecule influences dynein-mediated transport. In addition to reconciling prior observations with this new model for LIS1 function, we also discuss phylogenetic data that suggest that LIS1 may have coevolved with an autoinhibitory mode of cytoplasmic dynein regulation.https://elifesciences.org/articles/59737dyneinLIS1lissencephalydynactinnuclear migrationneuronal migration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Steven M Markus Matthew G Marzo Richard J McKenney |
spellingShingle |
Steven M Markus Matthew G Marzo Richard J McKenney New insights into the mechanism of dynein motor regulation by lissencephaly-1 eLife dynein LIS1 lissencephaly dynactin nuclear migration neuronal migration |
author_facet |
Steven M Markus Matthew G Marzo Richard J McKenney |
author_sort |
Steven M Markus |
title |
New insights into the mechanism of dynein motor regulation by lissencephaly-1 |
title_short |
New insights into the mechanism of dynein motor regulation by lissencephaly-1 |
title_full |
New insights into the mechanism of dynein motor regulation by lissencephaly-1 |
title_fullStr |
New insights into the mechanism of dynein motor regulation by lissencephaly-1 |
title_full_unstemmed |
New insights into the mechanism of dynein motor regulation by lissencephaly-1 |
title_sort |
new insights into the mechanism of dynein motor regulation by lissencephaly-1 |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2020-07-01 |
description |
Lissencephaly (‘smooth brain’) is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease – lissencephaly-1 (LIS1) – has been a focus of intense scrutiny since its first identification almost 30 years ago. LIS1 is a critical regulator of the microtubule motor cytoplasmic dynein, which transports numerous cargoes throughout the cell, and is a key effector of nuclear and neuronal transport during brain development. Here, we review the role of LIS1 in cellular dynein function and discuss recent key findings that have revealed a new mechanism by which this molecule influences dynein-mediated transport. In addition to reconciling prior observations with this new model for LIS1 function, we also discuss phylogenetic data that suggest that LIS1 may have coevolved with an autoinhibitory mode of cytoplasmic dynein regulation. |
topic |
dynein LIS1 lissencephaly dynactin nuclear migration neuronal migration |
url |
https://elifesciences.org/articles/59737 |
work_keys_str_mv |
AT stevenmmarkus newinsightsintothemechanismofdyneinmotorregulationbylissencephaly1 AT matthewgmarzo newinsightsintothemechanismofdyneinmotorregulationbylissencephaly1 AT richardjmckenney newinsightsintothemechanismofdyneinmotorregulationbylissencephaly1 |
_version_ |
1721458290819334144 |