Optimization of Collagen Chemical Crosslinking to Restore Biocompatibility of Tissue-Engineered Scaffolds

Optimization of Collagen Chemical Crosslinking to Restore Biocompatibility of Tissue-Engineered Scaffolds

Collagen scaffolds, one of the most used biomaterials in corneal tissue engineering, are frequently crosslinked to improve mechanical properties, enzyme tolerance, and thermal stability. Crosslinkers such as 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) are compatible with tissu...

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Bibliographic Details
Main Authors: Mohammad Mirazul Islam, Dina B. AbuSamra, Alexandru Chivu, Pablo Argüeso, Claes H. Dohlman, Hirak K. Patra, James Chodosh, Miguel González-Andrades
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
cornea
collagen
double-crosslinking
carbodiimide
glutaraldehyde
sodium metabisulfite
Online Access:https://www.mdpi.com/1999-4923/13/6/832

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https://www.mdpi.com/1999-4923/13/6/832

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