Terminal Protection of Small Molecule-Linked DNA for Small Molecule–Protein Interaction Assays

Terminal Protection of Small Molecule-Linked DNA for Small Molecule–Protein Interaction Assays

Methods for the detection of specific interactions between diverse proteins and various small-molecule ligands are of significant importance in understanding the mechanisms of many critical physiological processes of organisms. The techniques also represent a major avenue to drug screening, molecul...

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Bibliographic Details
Main Authors: Cui Hu, Zhan Wu, Hao Tang, Li-Juan Tang, Ru-Qin Yu, Jian-Hui Jiang
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:International Journal of Molecular Sciences
Subjects:
protein–ligand interaction
terminal protection
small molecule-linked DNA
signal amplification
nuclease
Online Access:http://www.mdpi.com/1422-0067/15/4/5221

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