COVID-19 in Cancer Patients From New York City: A Comparative Single Center Retrospective Analysis
In this retrospective study we analyze and compare clinical characteristics and outcomes of patients with and without cancer history who were infected with novel coronavirus disease 19 (COVID-19). Medical records were reviewed and a comparative analysis of 53 cancer and 135 non-cancer patients with...
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doaj-bc8c9391d1404daa8bc96e29feb4aae82020-11-25T03:51:57ZengSAGE PublishingCancer Control1073-27482020-10-012710.1177/1073274820960457COVID-19 in Cancer Patients From New York City: A Comparative Single Center Retrospective AnalysisPreethi Ramachandran MD, MRCP, FRCPath0Balachandar Kathirvelu MBBS, PhD1Abhishek Chakraborti MD2Mahesh Gajendran MD, MPH, FACP3Umar Zhahid MD4Snigdha Ghanta MD5Ifeanyichkwu Onukogu MD6Joshua Tetteh Narh MD7Jen C. Wang MD8Faiz Anwer MD, FACP9 Department of Hematology and Oncology, , Brooklyn, NY, USA Rehabilitation Sciences, , El Paso, TX, USA Department of Internal Medicine, , Brooklyn, NY, USA Department of Internal Medicine, Paul L. Foster School of Medicine, , El Paso, TX, USA Department of Nephrology, , Brooklyn, NY, USA Department of Internal Medicine, , Brooklyn, NY, USA Department of Internal Medicine, , Brooklyn, NY, USA Department of Internal Medicine, , Brooklyn, NY, USA New York Medical College, Hematology/Oncology research laboratory, , Brooklyn, NY, USA Tausig Cancer Center, Hematology/Oncology, Stem Cell Transplantation, , Cleveland, OH, USAIn this retrospective study we analyze and compare clinical characteristics and outcomes of patients with and without cancer history who were infected with novel coronavirus disease 19 (COVID-19). Medical records were reviewed and a comparative analysis of 53 cancer and 135 non-cancer patients with COVID-19 were summarized. Results: The median age for COVID-19 patients with and without cancer was 71.5 and 61.6 years, respectively. Patients aged 60 years and above were 86.8% and 60.7% in cancer and non-cancer groups, respectively. A high proportion of cases were seen in African Americans 73.6% (with cancer) and 75.6% (without cancer) followed by Hispanic patients. Male and female patients had a high percentage of prostate (39.3%) and breast (32%) cancer respectively. Prostate cancer (18.9%) and myeloma (11.3%) were common among solid and hematological cancers respectively. Hypertension and smoking were prevalent among cancer (83% and 41.5%) compared to non-cancer (67.4% and 9.6%) patients. The common symptoms in cancer patients were dyspnea (64.2%) followed by fever and cough (50.9%) compared to fever (68.1%) and cough (66.7%) in non-cancer patients. Cancer patients had higher levels of lactic acidosis, C-reactive protein, lactate dehydrogenase, and alkaline phosphatase than non-cancer patients (p < 0.05). Conclusions: Rapid clinical deterioration was seen in cancer patients who were aged 60 years and above. Higher mortality was seen in this subgroup, especially when they had associated hypertension and elevated levels of CRP and LDH.https://doi.org/10.1177/1073274820960457 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Preethi Ramachandran MD, MRCP, FRCPath Balachandar Kathirvelu MBBS, PhD Abhishek Chakraborti MD Mahesh Gajendran MD, MPH, FACP Umar Zhahid MD Snigdha Ghanta MD Ifeanyichkwu Onukogu MD Joshua Tetteh Narh MD Jen C. Wang MD Faiz Anwer MD, FACP |
spellingShingle |
Preethi Ramachandran MD, MRCP, FRCPath Balachandar Kathirvelu MBBS, PhD Abhishek Chakraborti MD Mahesh Gajendran MD, MPH, FACP Umar Zhahid MD Snigdha Ghanta MD Ifeanyichkwu Onukogu MD Joshua Tetteh Narh MD Jen C. Wang MD Faiz Anwer MD, FACP COVID-19 in Cancer Patients From New York City: A Comparative Single Center Retrospective Analysis Cancer Control |
author_facet |
Preethi Ramachandran MD, MRCP, FRCPath Balachandar Kathirvelu MBBS, PhD Abhishek Chakraborti MD Mahesh Gajendran MD, MPH, FACP Umar Zhahid MD Snigdha Ghanta MD Ifeanyichkwu Onukogu MD Joshua Tetteh Narh MD Jen C. Wang MD Faiz Anwer MD, FACP |
author_sort |
Preethi Ramachandran MD, MRCP, FRCPath |
title |
COVID-19 in Cancer Patients From New York City: A Comparative Single Center Retrospective Analysis |
title_short |
COVID-19 in Cancer Patients From New York City: A Comparative Single Center Retrospective Analysis |
title_full |
COVID-19 in Cancer Patients From New York City: A Comparative Single Center Retrospective Analysis |
title_fullStr |
COVID-19 in Cancer Patients From New York City: A Comparative Single Center Retrospective Analysis |
title_full_unstemmed |
COVID-19 in Cancer Patients From New York City: A Comparative Single Center Retrospective Analysis |
title_sort |
covid-19 in cancer patients from new york city: a comparative single center retrospective analysis |
publisher |
SAGE Publishing |
series |
Cancer Control |
issn |
1073-2748 |
publishDate |
2020-10-01 |
description |
In this retrospective study we analyze and compare clinical characteristics and outcomes of patients with and without cancer history who were infected with novel coronavirus disease 19 (COVID-19). Medical records were reviewed and a comparative analysis of 53 cancer and 135 non-cancer patients with COVID-19 were summarized. Results: The median age for COVID-19 patients with and without cancer was 71.5 and 61.6 years, respectively. Patients aged 60 years and above were 86.8% and 60.7% in cancer and non-cancer groups, respectively. A high proportion of cases were seen in African Americans 73.6% (with cancer) and 75.6% (without cancer) followed by Hispanic patients. Male and female patients had a high percentage of prostate (39.3%) and breast (32%) cancer respectively. Prostate cancer (18.9%) and myeloma (11.3%) were common among solid and hematological cancers respectively. Hypertension and smoking were prevalent among cancer (83% and 41.5%) compared to non-cancer (67.4% and 9.6%) patients. The common symptoms in cancer patients were dyspnea (64.2%) followed by fever and cough (50.9%) compared to fever (68.1%) and cough (66.7%) in non-cancer patients. Cancer patients had higher levels of lactic acidosis, C-reactive protein, lactate dehydrogenase, and alkaline phosphatase than non-cancer patients (p < 0.05). Conclusions: Rapid clinical deterioration was seen in cancer patients who were aged 60 years and above. Higher mortality was seen in this subgroup, especially when they had associated hypertension and elevated levels of CRP and LDH. |
url |
https://doi.org/10.1177/1073274820960457 |
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