Review of Geant4 Applications in Radiobiology
Introduction: Ionizing radiation is widely used in industry and medicine; however, it causes a significant health hazard by making microscopic damage to living tissue. Various biological parameters, including cell survival fraction and relative biological effectiveness, are taken into account to ass...
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doaj-bc96d05440f84b488eab1dc79a23d1f42020-11-25T01:49:37ZengMashhad University of Medical SciencesIranian Journal of Medical Physics2345-36722345-36722019-07-0116425526310.22038/ijmp.2018.31823.137511281Review of Geant4 Applications in RadiobiologySara Mohammadi0Mahdy Ebrahimi1Mohammad Taghi Bahreyni Toossi2Medical Physics Department, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Physics, Faculty of Rajaee, Quchan Branch, Technical and Vocational University (TVU), Khorasan Razavi, IranMedical Physics Department, Mashhad University of Medical Sciences, Mashhad, IranIntroduction: Ionizing radiation is widely used in industry and medicine; however, it causes a significant health hazard by making microscopic damage to living tissue. Various biological parameters, including cell survival fraction and relative biological effectiveness, are taken into account to assess the severity and extent of biological damages. Microdosimetry suffers from various shortcomings and limitations, but the development of some powerful simulation software has paved the way to resolve these problems in recent years. Material and Methods: In this study, the authors were looked for two keywords (Geant4 and radiobiology) in the title, abstracts, and keywords of Scopus and PubMed database articles. Results: More than 100 articles were found. The researchers extracted the articles that were devoted to the construction of different geometries for DNA, nucleus, and cells as simulate the parameters, such as relative biological effectiveness, SF, linear energy transfer, and single-strand breaks/double-strand breaks in the present study. Conclusion: Geant4 is one of the software commonly used to simulate biological factors. It has many properties, such as the ability to follow up physical processes in very low energy, open source code, and flexibility in complex geometries. In this paper, we reviewed some of the radiobiological parameters simulated with Geant4.http://ijmp.mums.ac.ir/article_11281_b353a3cc284428525cd7b8cc095611e5.pdfMonte Carlo MethodRadiobiologyCell SurvivalRelative biological effectivenessSingle Strand BreakDouble-Strand BreakParticle Therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sara Mohammadi Mahdy Ebrahimi Mohammad Taghi Bahreyni Toossi |
spellingShingle |
Sara Mohammadi Mahdy Ebrahimi Mohammad Taghi Bahreyni Toossi Review of Geant4 Applications in Radiobiology Iranian Journal of Medical Physics Monte Carlo Method Radiobiology Cell Survival Relative biological effectiveness Single Strand Break Double-Strand Break Particle Therapy |
author_facet |
Sara Mohammadi Mahdy Ebrahimi Mohammad Taghi Bahreyni Toossi |
author_sort |
Sara Mohammadi |
title |
Review of Geant4 Applications in Radiobiology |
title_short |
Review of Geant4 Applications in Radiobiology |
title_full |
Review of Geant4 Applications in Radiobiology |
title_fullStr |
Review of Geant4 Applications in Radiobiology |
title_full_unstemmed |
Review of Geant4 Applications in Radiobiology |
title_sort |
review of geant4 applications in radiobiology |
publisher |
Mashhad University of Medical Sciences |
series |
Iranian Journal of Medical Physics |
issn |
2345-3672 2345-3672 |
publishDate |
2019-07-01 |
description |
Introduction: Ionizing radiation is widely used in industry and medicine; however, it causes a significant health hazard by making microscopic damage to living tissue. Various biological parameters, including cell survival fraction and relative biological effectiveness, are taken into account to assess the severity and extent of biological damages. Microdosimetry suffers from various shortcomings and limitations, but the development of some powerful simulation software has paved the way to resolve these problems in recent years. Material and Methods: In this study, the authors were looked for two keywords (Geant4 and radiobiology) in the title, abstracts, and keywords of Scopus and PubMed database articles. Results: More than 100 articles were found. The researchers extracted the articles that were devoted to the construction of different geometries for DNA, nucleus, and cells as simulate the parameters, such as relative biological effectiveness, SF, linear energy transfer, and single-strand breaks/double-strand breaks in the present study. Conclusion: Geant4 is one of the software commonly used to simulate biological factors. It has many properties, such as the ability to follow up physical processes in very low energy, open source code, and flexibility in complex geometries. In this paper, we reviewed some of the radiobiological parameters simulated with Geant4. |
topic |
Monte Carlo Method Radiobiology Cell Survival Relative biological effectiveness Single Strand Break Double-Strand Break Particle Therapy |
url |
http://ijmp.mums.ac.ir/article_11281_b353a3cc284428525cd7b8cc095611e5.pdf |
work_keys_str_mv |
AT saramohammadi reviewofgeant4applicationsinradiobiology AT mahdyebrahimi reviewofgeant4applicationsinradiobiology AT mohammadtaghibahreynitoossi reviewofgeant4applicationsinradiobiology |
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