The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A Review
Tripterygium wilfordii Hook. f. (TWHF) is a traditional Chinese herbal medicine and widely used to treat diabetic kidney disease in China. Emerging evidences have revealed its ability to attenuate diabetic nephropathy (DN). Tripterygium wilfordii polyglycosides (TWPs), triptolide (TP), and celastrol...
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doaj-bc980b2fac3641358933ce0b1a211bb92021-09-21T04:24:53ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-09-01810.3389/fmed.2021.747922747922The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A ReviewPeng Liu0Jing Zhang1Yun Wang2Zhengri Shen3Chen Wang4Dan-Qian Chen5Xinping Qiu6Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, ChinaInstitute of Plant Resources, Yunnan University, Kunming, ChinaShunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, ChinaShunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, ChinaShunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, ChinaDepartment of Emergency, China-Japan Friendship Hospital, Beijing, ChinaShunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing, ChinaTripterygium wilfordii Hook. f. (TWHF) is a traditional Chinese herbal medicine and widely used to treat diabetic kidney disease in China. Emerging evidences have revealed its ability to attenuate diabetic nephropathy (DN). Tripterygium wilfordii polyglycosides (TWPs), triptolide (TP), and celastrol are predominantly active compounds isolated from TWHF. The effects and molecular mechanisms of TWHF and its active compounds have been investigated in recent years. Currently, it is becoming clearer that the effects of TWHF and its active compounds involve in anti-inflammation, anti-oxidative stress, anti-fibrosis, regulating autophagy, apoptosis, and protecting podocytes effect. This review presents an overview of the current findings related to the effects and mechanisms of TWHF and its active compounds in therapies of DN, thus providing a systematic understanding of the mechanisms and therapeutic targets by which TWHF and its active compounds affect cells and tissues in vitro and in vivo.https://www.frontiersin.org/articles/10.3389/fmed.2021.747922/fulldiabetic nephropathyTripterygium wilfordii Hook f.tripterygium wilfordii polyglycosidestriptolidecelastrol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Peng Liu Jing Zhang Yun Wang Zhengri Shen Chen Wang Dan-Qian Chen Xinping Qiu |
spellingShingle |
Peng Liu Jing Zhang Yun Wang Zhengri Shen Chen Wang Dan-Qian Chen Xinping Qiu The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A Review Frontiers in Medicine diabetic nephropathy Tripterygium wilfordii Hook f. tripterygium wilfordii polyglycosides triptolide celastrol |
author_facet |
Peng Liu Jing Zhang Yun Wang Zhengri Shen Chen Wang Dan-Qian Chen Xinping Qiu |
author_sort |
Peng Liu |
title |
The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A Review |
title_short |
The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A Review |
title_full |
The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A Review |
title_fullStr |
The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A Review |
title_full_unstemmed |
The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A Review |
title_sort |
active compounds and therapeutic target of tripterygium wilfordii hook. f. in attenuating proteinuria in diabetic nephropathy: a review |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2021-09-01 |
description |
Tripterygium wilfordii Hook. f. (TWHF) is a traditional Chinese herbal medicine and widely used to treat diabetic kidney disease in China. Emerging evidences have revealed its ability to attenuate diabetic nephropathy (DN). Tripterygium wilfordii polyglycosides (TWPs), triptolide (TP), and celastrol are predominantly active compounds isolated from TWHF. The effects and molecular mechanisms of TWHF and its active compounds have been investigated in recent years. Currently, it is becoming clearer that the effects of TWHF and its active compounds involve in anti-inflammation, anti-oxidative stress, anti-fibrosis, regulating autophagy, apoptosis, and protecting podocytes effect. This review presents an overview of the current findings related to the effects and mechanisms of TWHF and its active compounds in therapies of DN, thus providing a systematic understanding of the mechanisms and therapeutic targets by which TWHF and its active compounds affect cells and tissues in vitro and in vivo. |
topic |
diabetic nephropathy Tripterygium wilfordii Hook f. tripterygium wilfordii polyglycosides triptolide celastrol |
url |
https://www.frontiersin.org/articles/10.3389/fmed.2021.747922/full |
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