HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

Abstract Background Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflicting, we investigated the chromatin binding profile...

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Bibliographic Details
Main Authors: Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z. Brouwers-Vos, Maurien Pruis, André B. Mulder, Ulrich L. Günther, Joost H. A. Martens, Edo Vellenga, Jan Jacob Schuringa
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Cancer & Metabolism
Subjects:
Hypoxia induced factors (HIFs)
Human hematopoietic stem cells
Acute myeloid leukemia (AML)
Glycolysis
Hypoxia
BCR-ABL
Online Access:https://doi.org/10.1186/s40170-019-0206-y

Internet

https://doi.org/10.1186/s40170-019-0206-y

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