Flagellin/NLRC4 Pathway Rescues NLRP3-Inflammasome Defect in Dendritic Cells From HIV-Infected Patients: Perspective for New Adjuvant in Immunocompromised Individuals

Flagellin/NLRC4 Pathway Rescues NLRP3-Inflammasome Defect in Dendritic Cells From HIV-Infected Patients: Perspective for New Adjuvant in Immunocompromised Individuals

Introduction: NLRP3 inflammasome plays a key role in dendritic cells (DC) activation in response to vaccine adjuvants, however we previously showed that it is not properly activated in DC from HIV-infected patients (HIV-DC), explaining, at least in part, the poor response to immunization of these pa...

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Bibliographic Details
Main Authors: Edione Cristina dos Reis, Vinícius Nunes Cordeiro Leal, Jaíne Lima da Silva Soares, Fernanda Pereira Fernandes, Dhêmerson Souza de Lima, Bruna Cunha de Alencar, Alessandra Pontillo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
dendritic cell
inflammasome
HIV
flagellin
NLRC4
adjuvant
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01291/full

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