Detection of IVSII-1 Mutation of Beta Globin Gene in Carriers of Thalassemia Minor Using High-Resolution Melting Analysis

Detection of IVSII-1 Mutation of Beta Globin Gene in Carriers of Thalassemia Minor Using High-Resolution Melting Analysis

Background: Beta-thalassemia is one of the most common autosomal recessive disorders in the world population caused by more than 200 different mutations in the beta-globin chain. It is clinically classified as minor, intermediate and major. Beta-thalassemia is the most common monogenic disease in th...

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Bibliographic Details
Main Authors: Fatemeh Akhondi, Mojtaba Emadi-Baygi, Mansour Salehi, Parvaneh Nikpour
Format: Article
Language:fas
Published: Vesnu Publications 2016-02-01
Series:مجله دانشکده پزشکی اصفهان
Subjects:
Beta thalassemia minor
IVSII-1(G/A)
High-resolution melting (HRM)
Normalized plot
Difference plot
Online Access:http://jims.mui.ac.ir/index.php/jims/article/view/5567
Description
Summary:Background: Beta-thalassemia is one of the most common autosomal recessive disorders in the world population caused by more than 200 different mutations in the beta-globin chain. It is clinically classified as minor, intermediate and major. Beta-thalassemia is the most common monogenic disease in the Mediterranean countries, Middle East, Indian Subcontinent, and Southeast Asia and one of the widespread hereditary disorders in Iran. Among different
ISSN:1027-7595
1735-854X

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