Detection of IVSII-1 Mutation of Beta Globin Gene in Carriers of Thalassemia Minor Using High-Resolution Melting Analysis

Detection of IVSII-1 Mutation of Beta Globin Gene in Carriers of Thalassemia Minor Using High-Resolution Melting Analysis

Background: Beta-thalassemia is one of the most common autosomal recessive disorders in the world population caused by more than 200 different mutations in the beta-globin chain. It is clinically classified as minor, intermediate and major. Beta-thalassemia is the most common monogenic disease in th...

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Main Authors: Fatemeh Akhondi, Mojtaba Emadi-Baygi, Mansour Salehi, Parvaneh Nikpour
Format: Article
Language:fas
Published: Vesnu Publications 2016-02-01
Series:مجله دانشکده پزشکی اصفهان
Subjects:
Beta thalassemia minor
IVSII-1(G/A)
High-resolution melting (HRM)
Normalized plot
Difference plot
Online Access:http://jims.mui.ac.ir/index.php/jims/article/view/5567
id doaj-bc9c33ccc707451f99d799fc9667b190
record_format Article
spelling doaj-bc9c33ccc707451f99d799fc9667b1902020-11-25T01:33:43ZfasVesnu Publications مجله دانشکده پزشکی اصفهان1027-75951735-854X2016-02-0133363217921862099Detection of IVSII-1 Mutation of Beta Globin Gene in Carriers of Thalassemia Minor Using High-Resolution Melting AnalysisFatemeh Akhondi0Mojtaba Emadi-Baygi1Mansour Salehi2Parvaneh Nikpour3Department of Genetics, School of Basic Sciences, Shahrekord University, Shahrekord, IranAssistant Professor, Department of Genetics, School of Basic Sciences AND Research Institute of Biotechnology, Shahrekord University, Shahrekord, IranAssociate Professor, Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Applied Physiology Research Center AND Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease AND Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Beta-thalassemia is one of the most common autosomal recessive disorders in the world population caused by more than 200 different mutations in the beta-globin chain. It is clinically classified as minor, intermediate and major. Beta-thalassemia is the most common monogenic disease in the Mediterranean countries, Middle East, Indian Subcontinent, and Southeast Asia and one of the widespread hereditary disorders in Iran. Among differenthttp://jims.mui.ac.ir/index.php/jims/article/view/5567Beta thalassemia minorIVSII-1(G/A)High-resolution melting (HRM)Normalized plotDifference plot
collection DOAJ
language fas
format Article
sources DOAJ
author Fatemeh Akhondi
Mojtaba Emadi-Baygi
Mansour Salehi
Parvaneh Nikpour
spellingShingle Fatemeh Akhondi
Mojtaba Emadi-Baygi
Mansour Salehi
Parvaneh Nikpour
Detection of IVSII-1 Mutation of Beta Globin Gene in Carriers of Thalassemia Minor Using High-Resolution Melting Analysis
مجله دانشکده پزشکی اصفهان
Beta thalassemia minor
IVSII-1(G/A)
High-resolution melting (HRM)
Normalized plot
Difference plot
author_facet Fatemeh Akhondi
Mojtaba Emadi-Baygi
Mansour Salehi
Parvaneh Nikpour
author_sort Fatemeh Akhondi
title Detection of IVSII-1 Mutation of Beta Globin Gene in Carriers of Thalassemia Minor Using High-Resolution Melting Analysis
title_short Detection of IVSII-1 Mutation of Beta Globin Gene in Carriers of Thalassemia Minor Using High-Resolution Melting Analysis
title_full Detection of IVSII-1 Mutation of Beta Globin Gene in Carriers of Thalassemia Minor Using High-Resolution Melting Analysis
title_fullStr Detection of IVSII-1 Mutation of Beta Globin Gene in Carriers of Thalassemia Minor Using High-Resolution Melting Analysis
title_full_unstemmed Detection of IVSII-1 Mutation of Beta Globin Gene in Carriers of Thalassemia Minor Using High-Resolution Melting Analysis
title_sort detection of ivsii-1 mutation of beta globin gene in carriers of thalassemia minor using high-resolution melting analysis
publisher Vesnu Publications
series مجله دانشکده پزشکی اصفهان
issn 1027-7595
1735-854X
publishDate 2016-02-01
description Background: Beta-thalassemia is one of the most common autosomal recessive disorders in the world population caused by more than 200 different mutations in the beta-globin chain. It is clinically classified as minor, intermediate and major. Beta-thalassemia is the most common monogenic disease in the Mediterranean countries, Middle East, Indian Subcontinent, and Southeast Asia and one of the widespread hereditary disorders in Iran. Among different
topic Beta thalassemia minor
IVSII-1(G/A)
High-resolution melting (HRM)
Normalized plot
Difference plot
url http://jims.mui.ac.ir/index.php/jims/article/view/5567
work_keys_str_mv AT fatemehakhondi detectionofivsii1mutationofbetaglobingeneincarriersofthalassemiaminorusinghighresolutionmeltinganalysis
AT mojtabaemadibaygi detectionofivsii1mutationofbetaglobingeneincarriersofthalassemiaminorusinghighresolutionmeltinganalysis
AT mansoursalehi detectionofivsii1mutationofbetaglobingeneincarriersofthalassemiaminorusinghighresolutionmeltinganalysis
AT parvanehnikpour detectionofivsii1mutationofbetaglobingeneincarriersofthalassemiaminorusinghighresolutionmeltinganalysis
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