Microbial production of isoprenoids enabled by synthetic biology
Microorganisms transform inexpensive carbon sources into highly functionalized compounds without toxic by-product generation or significant energy consumption. By redesigning the natural biosynthetic pathways in an industrially suited host, microbial cell factories can produce complex compounds for...
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doaj-bca18159ebf44652a389973d69756cfe2020-11-24T23:05:17ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2013-04-01410.3389/fmicb.2013.0007546103Microbial production of isoprenoids enabled by synthetic biologyCheryl M. Immethun0Allison G. Hoynes-O’Connor1Andrea eBalassy2TAE SEOK eMOON3Washington University in St. LouisWashington University in St. LouisWashington University in St. LouisWashington University in St. LouisMicroorganisms transform inexpensive carbon sources into highly functionalized compounds without toxic by-product generation or significant energy consumption. By redesigning the natural biosynthetic pathways in an industrially suited host, microbial cell factories can produce complex compounds for a variety of industries. Isoprenoids include many medically important compounds such as antioxidants and anticancer and antimalarial drugs, all of which have been produced microbially. While a biosynthetic pathway could be simply transferred to the production host, the titers would become economically feasible when it is rationally designed, built, and optimized through synthetic biology tools. These tools have been implemented by a number of research groups, with new tools pledging further improvements in yields and expansion to new medically relevant compounds. This review focuses on the microbial production of isoprenoids for the health industry and the advancements though synthetic biology.http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00075/fullMetabolic EngineeringSynthetic Biologymicrobial biosynthesisisoprenoidshealth industry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cheryl M. Immethun Allison G. Hoynes-O’Connor Andrea eBalassy TAE SEOK eMOON |
spellingShingle |
Cheryl M. Immethun Allison G. Hoynes-O’Connor Andrea eBalassy TAE SEOK eMOON Microbial production of isoprenoids enabled by synthetic biology Frontiers in Microbiology Metabolic Engineering Synthetic Biology microbial biosynthesis isoprenoids health industry |
author_facet |
Cheryl M. Immethun Allison G. Hoynes-O’Connor Andrea eBalassy TAE SEOK eMOON |
author_sort |
Cheryl M. Immethun |
title |
Microbial production of isoprenoids enabled by synthetic biology |
title_short |
Microbial production of isoprenoids enabled by synthetic biology |
title_full |
Microbial production of isoprenoids enabled by synthetic biology |
title_fullStr |
Microbial production of isoprenoids enabled by synthetic biology |
title_full_unstemmed |
Microbial production of isoprenoids enabled by synthetic biology |
title_sort |
microbial production of isoprenoids enabled by synthetic biology |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2013-04-01 |
description |
Microorganisms transform inexpensive carbon sources into highly functionalized compounds without toxic by-product generation or significant energy consumption. By redesigning the natural biosynthetic pathways in an industrially suited host, microbial cell factories can produce complex compounds for a variety of industries. Isoprenoids include many medically important compounds such as antioxidants and anticancer and antimalarial drugs, all of which have been produced microbially. While a biosynthetic pathway could be simply transferred to the production host, the titers would become economically feasible when it is rationally designed, built, and optimized through synthetic biology tools. These tools have been implemented by a number of research groups, with new tools pledging further improvements in yields and expansion to new medically relevant compounds. This review focuses on the microbial production of isoprenoids for the health industry and the advancements though synthetic biology. |
topic |
Metabolic Engineering Synthetic Biology microbial biosynthesis isoprenoids health industry |
url |
http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00075/full |
work_keys_str_mv |
AT cherylmimmethun microbialproductionofisoprenoidsenabledbysyntheticbiology AT allisonghoynesoconnor microbialproductionofisoprenoidsenabledbysyntheticbiology AT andreaebalassy microbialproductionofisoprenoidsenabledbysyntheticbiology AT taeseokemoon microbialproductionofisoprenoidsenabledbysyntheticbiology |
_version_ |
1725626508578390016 |