Epigenetic Regulation and Its Therapeutic Potential in Pulmonary Hypertension
Recent advances in epigenetics have made a tremendous impact on our knowledge of biological phenomena and the environmental stressors on complex diseases. Understanding the mechanism of epigenetic reprogramming during the occurrence of pulmonary hypertension (PH) is important for advanced studies an...
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doaj-bca218126e164175ba0b7423574ae99f2020-11-24T23:09:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-03-01910.3389/fphar.2018.00241312600Epigenetic Regulation and Its Therapeutic Potential in Pulmonary HypertensionYu Wang0Lingling Yan1Ziming Zhang2Eric Prado3Linchen Fu4Xuefeng Xu5Lizhong Du6Department of Pediatrics, Children's Hospital of Zhejiang University, Hangzhou, ChinaDepartment of Pediatrics, Children's Hospital of Zhejiang University, Hangzhou, ChinaDepartment of Pediatrics, Children's Hospital of Zhejiang University, Hangzhou, ChinaLoma Linda University School of Medicine, Loma Linda, CA, United StatesDepartment of Pediatrics, Children's Hospital of Zhejiang University, Hangzhou, ChinaDepartment of Pediatrics, Children's Hospital of Zhejiang University, Hangzhou, ChinaDepartment of Pediatrics, Children's Hospital of Zhejiang University, Hangzhou, ChinaRecent advances in epigenetics have made a tremendous impact on our knowledge of biological phenomena and the environmental stressors on complex diseases. Understanding the mechanism of epigenetic reprogramming during the occurrence of pulmonary hypertension (PH) is important for advanced studies and clinical therapy. In this article, we review the discovery of novel epigenetic mechanisms associated with PH including DNA methylation, histone modification, and noncoding RNA interference. In addition, we highlight the role of epigenetic mechanisms in adult PAH resulting from undesirable perinatal environments—Extrauterine growth restriction (EUGR) and Intrauterine growth retardation (IUGR). Lastly, we give a comprehensive summary for the remaining challenges and discuss future methods of epigenetic targeted therapy for pulmonary hypertension.http://journal.frontiersin.org/article/10.3389/fphar.2018.00241/fullepigeneticspulmonary hypertensionDNA methylationhistone modificationsnoncoding RNAsIUGR |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Wang Lingling Yan Ziming Zhang Eric Prado Linchen Fu Xuefeng Xu Lizhong Du |
spellingShingle |
Yu Wang Lingling Yan Ziming Zhang Eric Prado Linchen Fu Xuefeng Xu Lizhong Du Epigenetic Regulation and Its Therapeutic Potential in Pulmonary Hypertension Frontiers in Pharmacology epigenetics pulmonary hypertension DNA methylation histone modifications noncoding RNAs IUGR |
author_facet |
Yu Wang Lingling Yan Ziming Zhang Eric Prado Linchen Fu Xuefeng Xu Lizhong Du |
author_sort |
Yu Wang |
title |
Epigenetic Regulation and Its Therapeutic Potential in Pulmonary Hypertension |
title_short |
Epigenetic Regulation and Its Therapeutic Potential in Pulmonary Hypertension |
title_full |
Epigenetic Regulation and Its Therapeutic Potential in Pulmonary Hypertension |
title_fullStr |
Epigenetic Regulation and Its Therapeutic Potential in Pulmonary Hypertension |
title_full_unstemmed |
Epigenetic Regulation and Its Therapeutic Potential in Pulmonary Hypertension |
title_sort |
epigenetic regulation and its therapeutic potential in pulmonary hypertension |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2018-03-01 |
description |
Recent advances in epigenetics have made a tremendous impact on our knowledge of biological phenomena and the environmental stressors on complex diseases. Understanding the mechanism of epigenetic reprogramming during the occurrence of pulmonary hypertension (PH) is important for advanced studies and clinical therapy. In this article, we review the discovery of novel epigenetic mechanisms associated with PH including DNA methylation, histone modification, and noncoding RNA interference. In addition, we highlight the role of epigenetic mechanisms in adult PAH resulting from undesirable perinatal environments—Extrauterine growth restriction (EUGR) and Intrauterine growth retardation (IUGR). Lastly, we give a comprehensive summary for the remaining challenges and discuss future methods of epigenetic targeted therapy for pulmonary hypertension. |
topic |
epigenetics pulmonary hypertension DNA methylation histone modifications noncoding RNAs IUGR |
url |
http://journal.frontiersin.org/article/10.3389/fphar.2018.00241/full |
work_keys_str_mv |
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