Subtypes of Ovarian Cancer and Ovarian Cancer Screening
Ovarian cancer is the foremost cause of gynecological cancer death in the developed world, as it is usually diagnosed at an advanced stage. In this paper we discuss current issues, the efficacy and problems associated with ovarian cancer screening, and compare the characteristics of ovarian cancer s...
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doaj-bca9ab019ceb49518bdae74ebbbabbbb2020-11-24T23:09:06ZengMDPI AGDiagnostics2075-44182017-03-01711210.3390/diagnostics7010012diagnostics7010012Subtypes of Ovarian Cancer and Ovarian Cancer ScreeningMasafumi Koshiyama0Noriomi Matsumura1Ikuo Konishi2Department of Gynecology and Obstetrics, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gynecology and Obstetrics, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Gynecology and Obstetrics, Kyoto University, Graduate School of Medicine, Sakyo-ku, Kyoto 606-8507, JapanOvarian cancer is the foremost cause of gynecological cancer death in the developed world, as it is usually diagnosed at an advanced stage. In this paper we discuss current issues, the efficacy and problems associated with ovarian cancer screening, and compare the characteristics of ovarian cancer subtypes. There are two types of ovarian cancer: Type I carcinomas, which are slow-growing, indolent neoplasms thought to arise from a precursor lesion, which are relatively common in Asia; and Type II carcinomas, which are clinically aggressive neoplasms that can develop de novo from serous tubal intraepithelial carcinomas (STIC) and/or ovarian surface epithelium and are common in Europe and the USA. One of the most famous studies on the subject reported that annual screening using CA125/transvaginal sonography (TVS) did not reduce the ovarian cancer mortality rate in the USA. In contrast, a recent study in the UK showed an overall average mortality reduction of 20% in the screening group. Another two studies further reported that the screening was associated with decreased stage at detection. Theoretically, annual screening using CA125/TVS could easily detect precursor lesions and could be more effective in Asia than in Europe and the USA. The detection of Type II ovarian carcinoma at an early stage remains an unresolved issue. The resolving power of CA125 or TVS screening alone is unlikely to be successful at resolving STICs. Biomarkers for the early detection of Type II carcinomas such as STICs need to be developed.http://www.mdpi.com/2075-4418/7/1/12subtypestwo types of ovarian cancerovarian cancer screeningCA125transvaginal sonography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masafumi Koshiyama Noriomi Matsumura Ikuo Konishi |
spellingShingle |
Masafumi Koshiyama Noriomi Matsumura Ikuo Konishi Subtypes of Ovarian Cancer and Ovarian Cancer Screening Diagnostics subtypes two types of ovarian cancer ovarian cancer screening CA125 transvaginal sonography |
author_facet |
Masafumi Koshiyama Noriomi Matsumura Ikuo Konishi |
author_sort |
Masafumi Koshiyama |
title |
Subtypes of Ovarian Cancer and Ovarian Cancer Screening |
title_short |
Subtypes of Ovarian Cancer and Ovarian Cancer Screening |
title_full |
Subtypes of Ovarian Cancer and Ovarian Cancer Screening |
title_fullStr |
Subtypes of Ovarian Cancer and Ovarian Cancer Screening |
title_full_unstemmed |
Subtypes of Ovarian Cancer and Ovarian Cancer Screening |
title_sort |
subtypes of ovarian cancer and ovarian cancer screening |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2017-03-01 |
description |
Ovarian cancer is the foremost cause of gynecological cancer death in the developed world, as it is usually diagnosed at an advanced stage. In this paper we discuss current issues, the efficacy and problems associated with ovarian cancer screening, and compare the characteristics of ovarian cancer subtypes. There are two types of ovarian cancer: Type I carcinomas, which are slow-growing, indolent neoplasms thought to arise from a precursor lesion, which are relatively common in Asia; and Type II carcinomas, which are clinically aggressive neoplasms that can develop de novo from serous tubal intraepithelial carcinomas (STIC) and/or ovarian surface epithelium and are common in Europe and the USA. One of the most famous studies on the subject reported that annual screening using CA125/transvaginal sonography (TVS) did not reduce the ovarian cancer mortality rate in the USA. In contrast, a recent study in the UK showed an overall average mortality reduction of 20% in the screening group. Another two studies further reported that the screening was associated with decreased stage at detection. Theoretically, annual screening using CA125/TVS could easily detect precursor lesions and could be more effective in Asia than in Europe and the USA. The detection of Type II ovarian carcinoma at an early stage remains an unresolved issue. The resolving power of CA125 or TVS screening alone is unlikely to be successful at resolving STICs. Biomarkers for the early detection of Type II carcinomas such as STICs need to be developed. |
topic |
subtypes two types of ovarian cancer ovarian cancer screening CA125 transvaginal sonography |
url |
http://www.mdpi.com/2075-4418/7/1/12 |
work_keys_str_mv |
AT masafumikoshiyama subtypesofovariancancerandovariancancerscreening AT noriomimatsumura subtypesofovariancancerandovariancancerscreening AT ikuokonishi subtypesofovariancancerandovariancancerscreening |
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