High muscle‐to‐fat ratio is associated with lower risk of chronic kidney disease development
Abstract Background Obesity, a known risk factor for chronic kidney disease (CKD), is generally assessed using body mass index (BMI). However, BMI may not effectively reflect body composition, and the impact of muscle‐to‐fat (MF) mass balance on kidney function has not been elucidated. This study ev...
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doaj-bcacf5b8844f475c96d3aeaf2db9ae402020-11-25T02:24:44ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092020-06-0111372673410.1002/jcsm.12549High muscle‐to‐fat ratio is associated with lower risk of chronic kidney disease developmentJong Hyun Jhee0Young Su Joo1Seong Hyeok Han2Tae‐Hyun Yoo3Shin‐Wook Kang4Jung Tak Park5Division of Nephrology, Department of Internal Medicine Gangnam Severance Hospital, Yonsei University College of Medicine Seoul KoreaDivision of Nephrology, Department of Internal Medicine Myongji Hospital Goyang Gyeonggi‐do KoreaDepartment of Internal Medicine, Institute of Kidney Disease Research Severance Hospital, Yonsei University College of Medicine Seoul KoreaDepartment of Internal Medicine, Institute of Kidney Disease Research Severance Hospital, Yonsei University College of Medicine Seoul KoreaDepartment of Internal Medicine, Institute of Kidney Disease Research Severance Hospital, Yonsei University College of Medicine Seoul KoreaDepartment of Internal Medicine, Institute of Kidney Disease Research Severance Hospital, Yonsei University College of Medicine Seoul KoreaAbstract Background Obesity, a known risk factor for chronic kidney disease (CKD), is generally assessed using body mass index (BMI). However, BMI may not effectively reflect body composition, and the impact of muscle‐to‐fat (MF) mass balance on kidney function has not been elucidated. This study evaluated the association between body muscle and fat mass balance, represented as the MF ratio, and incident CKD development. Methods Data were retrieved from a prospective community‐based cohort study (Korean Genome and Epidemiology Study). Muscle and fat mass were measured using multifrequency bioelectrical impedance analysis. The study endpoint was incident CKD (estimated glomerular filtration rate <60 mL/min/1.73 m2 in at least two or more consecutive measurements during the follow‐up period). Results Totally, 7682 participants were evaluated. Their mean age was 51.7 ± 8.7 years, and 48% of the subjects were men. During a median follow‐up of 140.0 (70.0–143.0) months, 633 (8.2%) subjects developed incident CKD. When the association between body composition and incident CKD was investigated, multivariable Cox proportional hazard analysis revealed that increase in MF ratio was related with a decreased risk of CKD development [per 1 increase in MF ratio: hazard ratio (HR), 0.86; 95% confidence interval (CI), 0.77–0.96; P = 0.008]. This association was also maintained when MF ratio was dichotomized according to sex‐specific median values (high vs. low: HR, 0.83; 95% CI, 0.70–0.98; P = 0.031). Analyses preformed in a propensity score matched group also revealed a similar decreased risk of incident CKD in high MF ratio participants (high vs. low: HR, 0.84; 95% CI, 0.71–0.98; P = 0.037). This relationship between MF ratio and incident CKD risk was consistently significant across subgroups stratified by age, sex, hypertension, estimated glomerular filtration rate categories, and proteinuria. Among different BMI groups (normal, overweight, and obese), the relationship between high MF ratio and lower incident CKD risk was significant only in overweight and obese subjects. Conclusions Lower fat mass relative to muscle mass may lower the risk of CKD development in individuals with normal renal function. This relationship seems more prominent in overweight and obese subjects than in normal weight subjects.https://doi.org/10.1002/jcsm.12549Muscle‐to‐fat ratioBody mass indexMuscle massFat massObesityChronic kidney disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jong Hyun Jhee Young Su Joo Seong Hyeok Han Tae‐Hyun Yoo Shin‐Wook Kang Jung Tak Park |
spellingShingle |
Jong Hyun Jhee Young Su Joo Seong Hyeok Han Tae‐Hyun Yoo Shin‐Wook Kang Jung Tak Park High muscle‐to‐fat ratio is associated with lower risk of chronic kidney disease development Journal of Cachexia, Sarcopenia and Muscle Muscle‐to‐fat ratio Body mass index Muscle mass Fat mass Obesity Chronic kidney disease |
author_facet |
Jong Hyun Jhee Young Su Joo Seong Hyeok Han Tae‐Hyun Yoo Shin‐Wook Kang Jung Tak Park |
author_sort |
Jong Hyun Jhee |
title |
High muscle‐to‐fat ratio is associated with lower risk of chronic kidney disease development |
title_short |
High muscle‐to‐fat ratio is associated with lower risk of chronic kidney disease development |
title_full |
High muscle‐to‐fat ratio is associated with lower risk of chronic kidney disease development |
title_fullStr |
High muscle‐to‐fat ratio is associated with lower risk of chronic kidney disease development |
title_full_unstemmed |
High muscle‐to‐fat ratio is associated with lower risk of chronic kidney disease development |
title_sort |
high muscle‐to‐fat ratio is associated with lower risk of chronic kidney disease development |
publisher |
Wiley |
series |
Journal of Cachexia, Sarcopenia and Muscle |
issn |
2190-5991 2190-6009 |
publishDate |
2020-06-01 |
description |
Abstract Background Obesity, a known risk factor for chronic kidney disease (CKD), is generally assessed using body mass index (BMI). However, BMI may not effectively reflect body composition, and the impact of muscle‐to‐fat (MF) mass balance on kidney function has not been elucidated. This study evaluated the association between body muscle and fat mass balance, represented as the MF ratio, and incident CKD development. Methods Data were retrieved from a prospective community‐based cohort study (Korean Genome and Epidemiology Study). Muscle and fat mass were measured using multifrequency bioelectrical impedance analysis. The study endpoint was incident CKD (estimated glomerular filtration rate <60 mL/min/1.73 m2 in at least two or more consecutive measurements during the follow‐up period). Results Totally, 7682 participants were evaluated. Their mean age was 51.7 ± 8.7 years, and 48% of the subjects were men. During a median follow‐up of 140.0 (70.0–143.0) months, 633 (8.2%) subjects developed incident CKD. When the association between body composition and incident CKD was investigated, multivariable Cox proportional hazard analysis revealed that increase in MF ratio was related with a decreased risk of CKD development [per 1 increase in MF ratio: hazard ratio (HR), 0.86; 95% confidence interval (CI), 0.77–0.96; P = 0.008]. This association was also maintained when MF ratio was dichotomized according to sex‐specific median values (high vs. low: HR, 0.83; 95% CI, 0.70–0.98; P = 0.031). Analyses preformed in a propensity score matched group also revealed a similar decreased risk of incident CKD in high MF ratio participants (high vs. low: HR, 0.84; 95% CI, 0.71–0.98; P = 0.037). This relationship between MF ratio and incident CKD risk was consistently significant across subgroups stratified by age, sex, hypertension, estimated glomerular filtration rate categories, and proteinuria. Among different BMI groups (normal, overweight, and obese), the relationship between high MF ratio and lower incident CKD risk was significant only in overweight and obese subjects. Conclusions Lower fat mass relative to muscle mass may lower the risk of CKD development in individuals with normal renal function. This relationship seems more prominent in overweight and obese subjects than in normal weight subjects. |
topic |
Muscle‐to‐fat ratio Body mass index Muscle mass Fat mass Obesity Chronic kidney disease |
url |
https://doi.org/10.1002/jcsm.12549 |
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