Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice
Previous studies have shown that rats withdrawn from long-term treatment with dopamine receptor blockers exhibit dopaminergic supersensitivity, which can be behaviorally evaluated by enhanced general activity observed in an open-field. Recently, it has been reported that co-treatment with the non-be...
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Associação Brasileira de Divulgação Científica
2002-02-01
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doaj-bcaed97e5b4e42b7a985faa89a0850ee2020-11-25T02:47:14ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2002-02-0135223724210.1590/S0100-879X2002000200013Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in miceC.M.T. QueirozF.B. AlcântaraA.M.L. YagüeT. BibancosR. Frussa-FilhoPrevious studies have shown that rats withdrawn from long-term treatment with dopamine receptor blockers exhibit dopaminergic supersensitivity, which can be behaviorally evaluated by enhanced general activity observed in an open-field. Recently, it has been reported that co-treatment with the non-benzodiazepine anxiolytic buspirone attenuates the development of haloperidol-induced dopaminergic supersensitivity measured by open-field behavior of rats. The aims of the present study were: 1) to determine, as previously reported for rats, if mice withdrawn from long-term neuroleptic treatment would also develop dopaminergic supersensitivity using open-field behavior as an experimental paradigm, and 2) to examine if acute buspirone administration would attenuate the expression of this behavioral dopaminergic supersensitivity. Withdrawal from long-term haloperidol treatment (2.5 mg/kg, once daily, for 20 days) induced a significant (30%) increase in ambulation frequency (i.e., number of squares crossed in 5-min observation sessions) but did not modify rearing frequency or immobility duration in 3-month-old EPM-M1 male mice observed in the open-field apparatus. Acute intraperitoneal injection of buspirone (3.0 and 10 but not 1.0 mg/kg, 12-13 animals per group) 30 min before open-field exposure abolished the increase in locomotion frequency induced by haloperidol withdrawal. These data suggest that the open-field behavior of mice can be used to detect dopaminergic supersensitivity, whose expression is abolished by acute buspirone administration.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200013BuspironeHaloperidolDopaminergic supersensitivityTardive dyskinesiaBehaviorMice |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
C.M.T. Queiroz F.B. Alcântara A.M.L. Yagüe T. Bibancos R. Frussa-Filho |
spellingShingle |
C.M.T. Queiroz F.B. Alcântara A.M.L. Yagüe T. Bibancos R. Frussa-Filho Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice Brazilian Journal of Medical and Biological Research Buspirone Haloperidol Dopaminergic supersensitivity Tardive dyskinesia Behavior Mice |
author_facet |
C.M.T. Queiroz F.B. Alcântara A.M.L. Yagüe T. Bibancos R. Frussa-Filho |
author_sort |
C.M.T. Queiroz |
title |
Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice |
title_short |
Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice |
title_full |
Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice |
title_fullStr |
Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice |
title_full_unstemmed |
Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice |
title_sort |
acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice |
publisher |
Associação Brasileira de Divulgação Científica |
series |
Brazilian Journal of Medical and Biological Research |
issn |
0100-879X 1414-431X |
publishDate |
2002-02-01 |
description |
Previous studies have shown that rats withdrawn from long-term treatment with dopamine receptor blockers exhibit dopaminergic supersensitivity, which can be behaviorally evaluated by enhanced general activity observed in an open-field. Recently, it has been reported that co-treatment with the non-benzodiazepine anxiolytic buspirone attenuates the development of haloperidol-induced dopaminergic supersensitivity measured by open-field behavior of rats. The aims of the present study were: 1) to determine, as previously reported for rats, if mice withdrawn from long-term neuroleptic treatment would also develop dopaminergic supersensitivity using open-field behavior as an experimental paradigm, and 2) to examine if acute buspirone administration would attenuate the expression of this behavioral dopaminergic supersensitivity. Withdrawal from long-term haloperidol treatment (2.5 mg/kg, once daily, for 20 days) induced a significant (30%) increase in ambulation frequency (i.e., number of squares crossed in 5-min observation sessions) but did not modify rearing frequency or immobility duration in 3-month-old EPM-M1 male mice observed in the open-field apparatus. Acute intraperitoneal injection of buspirone (3.0 and 10 but not 1.0 mg/kg, 12-13 animals per group) 30 min before open-field exposure abolished the increase in locomotion frequency induced by haloperidol withdrawal. These data suggest that the open-field behavior of mice can be used to detect dopaminergic supersensitivity, whose expression is abolished by acute buspirone administration. |
topic |
Buspirone Haloperidol Dopaminergic supersensitivity Tardive dyskinesia Behavior Mice |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200013 |
work_keys_str_mv |
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