The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural Correlates
Introduction: Memory alterations are common in Parkinson's disease (PD) patients but the mechanisms involved in these deficits remain poorly understood. The study aims to explore the profile of episodic memory deficits in non-demented early PD patients.Methods: We obtained neurological, cogniti...
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2020-04-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00240/full |
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DOAJ |
language |
English |
format |
Article |
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DOAJ |
author |
Andrea Horta-Barba Andrea Horta-Barba Andrea Horta-Barba Andrea Horta-Barba Javier Pagonabarraga Javier Pagonabarraga Javier Pagonabarraga Javier Pagonabarraga Saül Martínez-Horta Saül Martínez-Horta Saül Martínez-Horta Saül Martínez-Horta Juan Marín-Lahoz Juan Marín-Lahoz Juan Marín-Lahoz Frederic Sampedro Frederic Sampedro Frederic Sampedro Ramón Fernández-Bobadilla Ramón Fernández-Bobadilla M. Ángeles Botí M. Ángeles Botí Helena Bejr-Kasem Helena Bejr-Kasem Helena Bejr-Kasem Ignacio Aracil-Bolaños Ignacio Aracil-Bolaños Jesus Pérez-Pérez Jesus Pérez-Pérez Jesus Pérez-Pérez Berta Pascual-Sedano Berta Pascual-Sedano Berta Pascual-Sedano Antonia Campolongo Antonia Campolongo Cristina Izquierdo Beatriz Gómez-Ansón Beatriz Gómez-Ansón Beatriz Gómez-Ansón Jaime Kulisevsky Jaime Kulisevsky Jaime Kulisevsky Jaime Kulisevsky |
spellingShingle |
Andrea Horta-Barba Andrea Horta-Barba Andrea Horta-Barba Andrea Horta-Barba Javier Pagonabarraga Javier Pagonabarraga Javier Pagonabarraga Javier Pagonabarraga Saül Martínez-Horta Saül Martínez-Horta Saül Martínez-Horta Saül Martínez-Horta Juan Marín-Lahoz Juan Marín-Lahoz Juan Marín-Lahoz Frederic Sampedro Frederic Sampedro Frederic Sampedro Ramón Fernández-Bobadilla Ramón Fernández-Bobadilla M. Ángeles Botí M. Ángeles Botí Helena Bejr-Kasem Helena Bejr-Kasem Helena Bejr-Kasem Ignacio Aracil-Bolaños Ignacio Aracil-Bolaños Jesus Pérez-Pérez Jesus Pérez-Pérez Jesus Pérez-Pérez Berta Pascual-Sedano Berta Pascual-Sedano Berta Pascual-Sedano Antonia Campolongo Antonia Campolongo Cristina Izquierdo Beatriz Gómez-Ansón Beatriz Gómez-Ansón Beatriz Gómez-Ansón Jaime Kulisevsky Jaime Kulisevsky Jaime Kulisevsky Jaime Kulisevsky The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural Correlates Frontiers in Neurology PD-MCI Free and Cued Selective Reminding Rest Parkinson's disease memory episodic memory |
author_facet |
Andrea Horta-Barba Andrea Horta-Barba Andrea Horta-Barba Andrea Horta-Barba Javier Pagonabarraga Javier Pagonabarraga Javier Pagonabarraga Javier Pagonabarraga Saül Martínez-Horta Saül Martínez-Horta Saül Martínez-Horta Saül Martínez-Horta Juan Marín-Lahoz Juan Marín-Lahoz Juan Marín-Lahoz Frederic Sampedro Frederic Sampedro Frederic Sampedro Ramón Fernández-Bobadilla Ramón Fernández-Bobadilla M. Ángeles Botí M. Ángeles Botí Helena Bejr-Kasem Helena Bejr-Kasem Helena Bejr-Kasem Ignacio Aracil-Bolaños Ignacio Aracil-Bolaños Jesus Pérez-Pérez Jesus Pérez-Pérez Jesus Pérez-Pérez Berta Pascual-Sedano Berta Pascual-Sedano Berta Pascual-Sedano Antonia Campolongo Antonia Campolongo Cristina Izquierdo Beatriz Gómez-Ansón Beatriz Gómez-Ansón Beatriz Gómez-Ansón Jaime Kulisevsky Jaime Kulisevsky Jaime Kulisevsky Jaime Kulisevsky |
author_sort |
Andrea Horta-Barba |
title |
The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural Correlates |
title_short |
The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural Correlates |
title_full |
The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural Correlates |
title_fullStr |
The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural Correlates |
title_full_unstemmed |
The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural Correlates |
title_sort |
free and cued selective reminding test in parkinson's disease mild cognitive impairment: discriminative accuracy and neural correlates |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2020-04-01 |
description |
Introduction: Memory alterations are common in Parkinson's disease (PD) patients but the mechanisms involved in these deficits remain poorly understood. The study aims to explore the profile of episodic memory deficits in non-demented early PD patients.Methods: We obtained neurological, cognitive and behavioral data from 114 PD patients and 41 healthy controls (HC). PD participants were grouped as normal cognition (PD-NC) and mild cognitive impairment (PD-MCI) according to the Level II criteria of the Movement Disorders Society Task Force (MDS-TF). We evaluate the performance amongst groups on an episodic memory task using the Free and Cued Selective Reminding Test (FCSRT). Additionally, gray matter volume (GMV) voxel based morphometry, and mean diffusivity (MD) analyses were conducted in a subset of patients to explore the structural brain correlates of FCSRT performance.Results: Performance on all subscores of the FCSRT was significantly worse in PD-MCI than in PD-NC and HC. Delayed total recall (DTR) subscore was the best at differentiating PD-NC from PD-MCI. Using crosstabulation, DTR allowed identification of PD-MCI patients with an accuracy of 80%. Delayed free and cued recall was associated with decreased GMV and increased MD in multiple fronto-temporal and parietal areas.Conclusion: Encoding and retrieval deficits are a main characteristic of PD-MCI and are associated with structural damage in temporal, parietal and prefrontal areas. |
topic |
PD-MCI Free and Cued Selective Reminding Rest Parkinson's disease memory episodic memory |
url |
https://www.frontiersin.org/article/10.3389/fneur.2020.00240/full |
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doaj-bcbc3bc4fdbf49749042a01e7a324d722020-11-25T01:43:18ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-04-011110.3389/fneur.2020.00240513216The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural CorrelatesAndrea Horta-Barba0Andrea Horta-Barba1Andrea Horta-Barba2Andrea Horta-Barba3Javier Pagonabarraga4Javier Pagonabarraga5Javier Pagonabarraga6Javier Pagonabarraga7Saül Martínez-Horta8Saül Martínez-Horta9Saül Martínez-Horta10Saül Martínez-Horta11Juan Marín-Lahoz12Juan Marín-Lahoz13Juan Marín-Lahoz14Frederic Sampedro15Frederic Sampedro16Frederic Sampedro17Ramón Fernández-Bobadilla18Ramón Fernández-Bobadilla19M. Ángeles Botí20M. Ángeles Botí21Helena Bejr-Kasem22Helena Bejr-Kasem23Helena Bejr-Kasem24Ignacio Aracil-Bolaños25Ignacio Aracil-Bolaños26Jesus Pérez-Pérez27Jesus Pérez-Pérez28Jesus Pérez-Pérez29Berta Pascual-Sedano30Berta Pascual-Sedano31Berta Pascual-Sedano32Antonia Campolongo33Antonia Campolongo34Cristina Izquierdo35Beatriz Gómez-Ansón36Beatriz Gómez-Ansón37Beatriz Gómez-Ansón38Jaime Kulisevsky39Jaime Kulisevsky40Jaime Kulisevsky41Jaime Kulisevsky42Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainCentro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainAutonomous University of Barcelona, Barcelona, SpainMovement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainCentro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainAutonomous University of Barcelona, Barcelona, SpainMovement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainCentro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainAutonomous University of Barcelona, Barcelona, SpainMovement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, SpainCentro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainAutonomous University of Barcelona, Barcelona, SpainMovement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainCentro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainMovement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainMovement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainMovement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainCentro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainMovement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainMovement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainCentro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainMovement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, SpainCentro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainAutonomous University of Barcelona, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainCentro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainAutonomous University of Barcelona, Barcelona, SpainNeuroradiology Unit, Sant Pau Hospital, Barcelona, SpainMovement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, SpainBiomedical Research Institute (IIB-Sant Pau), Barcelona, SpainCentro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Barcelona, SpainAutonomous University of Barcelona, Barcelona, SpainIntroduction: Memory alterations are common in Parkinson's disease (PD) patients but the mechanisms involved in these deficits remain poorly understood. The study aims to explore the profile of episodic memory deficits in non-demented early PD patients.Methods: We obtained neurological, cognitive and behavioral data from 114 PD patients and 41 healthy controls (HC). PD participants were grouped as normal cognition (PD-NC) and mild cognitive impairment (PD-MCI) according to the Level II criteria of the Movement Disorders Society Task Force (MDS-TF). We evaluate the performance amongst groups on an episodic memory task using the Free and Cued Selective Reminding Test (FCSRT). Additionally, gray matter volume (GMV) voxel based morphometry, and mean diffusivity (MD) analyses were conducted in a subset of patients to explore the structural brain correlates of FCSRT performance.Results: Performance on all subscores of the FCSRT was significantly worse in PD-MCI than in PD-NC and HC. Delayed total recall (DTR) subscore was the best at differentiating PD-NC from PD-MCI. Using crosstabulation, DTR allowed identification of PD-MCI patients with an accuracy of 80%. Delayed free and cued recall was associated with decreased GMV and increased MD in multiple fronto-temporal and parietal areas.Conclusion: Encoding and retrieval deficits are a main characteristic of PD-MCI and are associated with structural damage in temporal, parietal and prefrontal areas.https://www.frontiersin.org/article/10.3389/fneur.2020.00240/fullPD-MCIFree and Cued Selective Reminding RestParkinson's diseasememoryepisodic memory |