Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin
Two new and improved procedures were developed for the synthesis of 1-(1-naphthyloxy)-2,3-epoxypropane as an important intermediate in the production of the beta-blocker and antioxidant 1-[(1-methylethyl)amino]-3-(1-naphthyloxy)- 2-propanol (propranolol). Both base homogeneous and heterogeneous PTC...
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Serbian Chemical Society
2006-01-01
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doaj-bcbfaf4f346740e6ae814a10435a82272020-12-24T14:30:55ZengSerbian Chemical Society Journal of the Serbian Chemical Society0352-51391820-74212006-01-01718-986787710.2298/JSC0609867J0352-51390609867JCatalysis in the alkylation reaction of 1-naphthol with epichlorohydrinJovanović Slobodanka0Vico-Stevanović Milanka1Uglješić-Kilibarda Dragana2Popadić Dragica3Simić Slobodanka4Dželetović Dijamanda5Galenika a.d., BeogradGalenika a.d., BeogradGalenika a.d., BeogradGalenika a.d., BeogradGalenika a.d., BeogradGalenika a.d., BeogradTwo new and improved procedures were developed for the synthesis of 1-(1-naphthyloxy)-2,3-epoxypropane as an important intermediate in the production of the beta-blocker and antioxidant 1-[(1-methylethyl)amino]-3-(1-naphthyloxy)- 2-propanol (propranolol). Both base homogeneous and heterogeneous PTC catalysis were employed. High yields and remarkable selectivity were achieved. The improved purity is particularly important, in view of the quality requirements for propranolol hydrochloride as an active pharmaceutical ingredient.http://www.doiserbia.nb.rs/img/doi/0352-5139/2006/0352-51390609867J.pdfheterogeneous ptc catalysisbase homogeneous catalysisselectivityyieldmodel system |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jovanović Slobodanka Vico-Stevanović Milanka Uglješić-Kilibarda Dragana Popadić Dragica Simić Slobodanka Dželetović Dijamanda |
spellingShingle |
Jovanović Slobodanka Vico-Stevanović Milanka Uglješić-Kilibarda Dragana Popadić Dragica Simić Slobodanka Dželetović Dijamanda Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin Journal of the Serbian Chemical Society heterogeneous ptc catalysis base homogeneous catalysis selectivity yield model system |
author_facet |
Jovanović Slobodanka Vico-Stevanović Milanka Uglješić-Kilibarda Dragana Popadić Dragica Simić Slobodanka Dželetović Dijamanda |
author_sort |
Jovanović Slobodanka |
title |
Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin |
title_short |
Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin |
title_full |
Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin |
title_fullStr |
Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin |
title_full_unstemmed |
Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin |
title_sort |
catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin |
publisher |
Serbian Chemical Society |
series |
Journal of the Serbian Chemical Society |
issn |
0352-5139 1820-7421 |
publishDate |
2006-01-01 |
description |
Two new and improved procedures were developed for the synthesis of 1-(1-naphthyloxy)-2,3-epoxypropane as an important intermediate in the production of the beta-blocker and antioxidant 1-[(1-methylethyl)amino]-3-(1-naphthyloxy)- 2-propanol (propranolol). Both base homogeneous and heterogeneous PTC catalysis were employed. High yields and remarkable selectivity were achieved. The improved purity is particularly important, in view of the quality requirements for propranolol hydrochloride as an active pharmaceutical ingredient. |
topic |
heterogeneous ptc catalysis base homogeneous catalysis selectivity yield model system |
url |
http://www.doiserbia.nb.rs/img/doi/0352-5139/2006/0352-51390609867J.pdf |
work_keys_str_mv |
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_version_ |
1724371797650964480 |