Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin

Two new and improved procedures were developed for the synthesis of 1-(1-naphthyloxy)-2,3-epoxypropane as an important intermediate in the production of the beta-blocker and antioxidant 1-[(1-methylethyl)amino]-3-(1-naphthyloxy)- 2-propanol (propranolol). Both base homogeneous and heterogeneous PTC...

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Main Authors:	Jovanović Slobodanka, Vico-Stevanović Milanka, Uglješić-Kilibarda Dragana, Popadić Dragica, Simić Slobodanka, Dželetović Dijamanda
Format:	Article
Language:	English
Published:	Serbian Chemical Society 2006-01-01
Series:	Journal of the Serbian Chemical Society
Subjects:	heterogeneous ptc catalysis base homogeneous catalysis selectivity yield model system
Online Access:	http://www.doiserbia.nb.rs/img/doi/0352-5139/2006/0352-51390609867J.pdf

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record_format	Article
spelling	doaj-bcbfaf4f346740e6ae814a10435a82272020-12-24T14:30:55ZengSerbian Chemical Society Journal of the Serbian Chemical Society0352-51391820-74212006-01-01718-986787710.2298/JSC0609867J0352-51390609867JCatalysis in the alkylation reaction of 1-naphthol with epichlorohydrinJovanović Slobodanka0Vico-Stevanović Milanka1Uglješić-Kilibarda Dragana2Popadić Dragica3Simić Slobodanka4Dželetović Dijamanda5Galenika a.d., BeogradGalenika a.d., BeogradGalenika a.d., BeogradGalenika a.d., BeogradGalenika a.d., BeogradGalenika a.d., BeogradTwo new and improved procedures were developed for the synthesis of 1-(1-naphthyloxy)-2,3-epoxypropane as an important intermediate in the production of the beta-blocker and antioxidant 1-[(1-methylethyl)amino]-3-(1-naphthyloxy)- 2-propanol (propranolol). Both base homogeneous and heterogeneous PTC catalysis were employed. High yields and remarkable selectivity were achieved. The improved purity is particularly important, in view of the quality requirements for propranolol hydrochloride as an active pharmaceutical ingredient.http://www.doiserbia.nb.rs/img/doi/0352-5139/2006/0352-51390609867J.pdfheterogeneous ptc catalysisbase homogeneous catalysisselectivityyieldmodel system
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jovanović Slobodanka Vico-Stevanović Milanka Uglješić-Kilibarda Dragana Popadić Dragica Simić Slobodanka Dželetović Dijamanda
spellingShingle	Jovanović Slobodanka Vico-Stevanović Milanka Uglješić-Kilibarda Dragana Popadić Dragica Simić Slobodanka Dželetović Dijamanda Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin Journal of the Serbian Chemical Society heterogeneous ptc catalysis base homogeneous catalysis selectivity yield model system
author_facet	Jovanović Slobodanka Vico-Stevanović Milanka Uglješić-Kilibarda Dragana Popadić Dragica Simić Slobodanka Dželetović Dijamanda
author_sort	Jovanović Slobodanka
title	Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin
title_short	Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin
title_full	Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin
title_fullStr	Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin
title_full_unstemmed	Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin
title_sort	catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin
publisher	Serbian Chemical Society
series	Journal of the Serbian Chemical Society
issn	0352-5139 1820-7421
publishDate	2006-01-01
description	Two new and improved procedures were developed for the synthesis of 1-(1-naphthyloxy)-2,3-epoxypropane as an important intermediate in the production of the beta-blocker and antioxidant 1-[(1-methylethyl)amino]-3-(1-naphthyloxy)- 2-propanol (propranolol). Both base homogeneous and heterogeneous PTC catalysis were employed. High yields and remarkable selectivity were achieved. The improved purity is particularly important, in view of the quality requirements for propranolol hydrochloride as an active pharmaceutical ingredient.
topic	heterogeneous ptc catalysis base homogeneous catalysis selectivity yield model system
url	http://www.doiserbia.nb.rs/img/doi/0352-5139/2006/0352-51390609867J.pdf
work_keys_str_mv	AT jovanovicslobodanka catalysisinthealkylationreactionof1naphtholwithepichlorohydrin AT vicostevanovicmilanka catalysisinthealkylationreactionof1naphtholwithepichlorohydrin AT ugljesickilibardadragana catalysisinthealkylationreactionof1naphtholwithepichlorohydrin AT popadicdragica catalysisinthealkylationreactionof1naphtholwithepichlorohydrin AT simicslobodanka catalysisinthealkylationreactionof1naphtholwithepichlorohydrin AT dzeletovicdijamanda catalysisinthealkylationreactionof1naphtholwithepichlorohydrin
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Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin

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