The role of regulatory T cells in cancer immunology
Theresa L Whiteside University of Pittsburgh Cancer Institute, Pittsburgh, PA, US Abstract: Regulatory T cells (Treg) are generally considered to be significant contributors to tumor escape from the host immune system. Emerging evidence suggests, however, that in some human cancers, Treg are necessa...
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doaj-bcc381b5144e4c089005c1c18f607e552020-11-24T22:34:22ZengDove Medical PressImmunoTargets and Therapy2253-15562015-08-012015Issue 115917122966The role of regulatory T cells in cancer immunologyWhiteside TLTheresa L Whiteside University of Pittsburgh Cancer Institute, Pittsburgh, PA, US Abstract: Regulatory T cells (Treg) are generally considered to be significant contributors to tumor escape from the host immune system. Emerging evidence suggests, however, that in some human cancers, Treg are necessary to control chronic inflammation, prevent tissue damage, and limit inflammation-associated cancer development. The dual role of Treg in cancer and underpinnings of Treg diversity are not well understood. This review attempts to provide insights into the importance of Treg subsets in cancer development and its progression. It also considers the role of Treg as potential biomarkers of clinical outcome in cancer. The strategies for monitoring Treg in cancer patients are discussed as is the need for caution in the use of therapies which indiscriminately ablate Treg. A greater understanding of molecular pathways operating in various tumor microenvironments is necessary for defining the Treg impact on cancer and for selecting immunotherapies targeting Treg. Keywords: cancer, regulatory T cells, tumor microenvironment, immune suppression, anti-Treg therapieshttps://www.dovepress.com/the-role-of-regulatory-t-cells-in-cancer-immunology-peer-reviewed-article-ITTcancerregulatory T cellstumor microenvironmentimmune suppressionanti-Treg therapies |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Whiteside TL |
spellingShingle |
Whiteside TL The role of regulatory T cells in cancer immunology ImmunoTargets and Therapy cancer regulatory T cells tumor microenvironment immune suppression anti-Treg therapies |
author_facet |
Whiteside TL |
author_sort |
Whiteside TL |
title |
The role of regulatory T cells in cancer immunology |
title_short |
The role of regulatory T cells in cancer immunology |
title_full |
The role of regulatory T cells in cancer immunology |
title_fullStr |
The role of regulatory T cells in cancer immunology |
title_full_unstemmed |
The role of regulatory T cells in cancer immunology |
title_sort |
role of regulatory t cells in cancer immunology |
publisher |
Dove Medical Press |
series |
ImmunoTargets and Therapy |
issn |
2253-1556 |
publishDate |
2015-08-01 |
description |
Theresa L Whiteside University of Pittsburgh Cancer Institute, Pittsburgh, PA, US Abstract: Regulatory T cells (Treg) are generally considered to be significant contributors to tumor escape from the host immune system. Emerging evidence suggests, however, that in some human cancers, Treg are necessary to control chronic inflammation, prevent tissue damage, and limit inflammation-associated cancer development. The dual role of Treg in cancer and underpinnings of Treg diversity are not well understood. This review attempts to provide insights into the importance of Treg subsets in cancer development and its progression. It also considers the role of Treg as potential biomarkers of clinical outcome in cancer. The strategies for monitoring Treg in cancer patients are discussed as is the need for caution in the use of therapies which indiscriminately ablate Treg. A greater understanding of molecular pathways operating in various tumor microenvironments is necessary for defining the Treg impact on cancer and for selecting immunotherapies targeting Treg. Keywords: cancer, regulatory T cells, tumor microenvironment, immune suppression, anti-Treg therapies |
topic |
cancer regulatory T cells tumor microenvironment immune suppression anti-Treg therapies |
url |
https://www.dovepress.com/the-role-of-regulatory-t-cells-in-cancer-immunology-peer-reviewed-article-ITT |
work_keys_str_mv |
AT whitesidetl theroleofregulatorytcellsincancerimmunology AT whitesidetl roleofregulatorytcellsincancerimmunology |
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