Associations between dietary micronutrient intake and molecular-Bacterial Vaginosis
Abstract Objectives Bacterial vaginosis (BV), a clinical condition characterized by decreased vaginal Lactobacillus spp., is difficult to treat. We examined associations between micronutrient intake and a low-Lactobacillus vaginal microbiota as assessed by molecular methods (termed “molecular-BV”)....
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doaj-bcdb8490698e4d8198e89328473b00a72020-11-25T03:56:18ZengBMCReproductive Health1742-47552019-10-011611810.1186/s12978-019-0814-6Associations between dietary micronutrient intake and molecular-Bacterial VaginosisSusan Tuddenham0Khalil G. Ghanem1Laura E. Caulfield2Alisha J. Rovner3Courtney Robinson4Rupak Shivakoti5Ryan Miller6Anne Burke7Catherine Murphy8Jacques Ravel9Rebecca M. Brotman10Department of Medicine, Johns Hopkins University School of MedicineDepartment of Medicine, Johns Hopkins University School of MedicineCenter for Human Nutrition, Johns Hopkins Bloomberg School of Public HealthDepartment of Behavioral Health and Nutrition, University of DelawareInstitute for Genome Sciences, University of Maryland School of MedicineDepartment of Epidemiology, Columbia University Mailman School of Public HealthDepartment of Pediatrics, University of Maryland School of MedicineDepartment of Obstetrics and Gynecology, Johns Hopkins University School of MedicineDepartment of Medicine, Johns Hopkins University School of MedicineInstitute for Genome Sciences, University of Maryland School of MedicineInstitute for Genome Sciences, University of Maryland School of MedicineAbstract Objectives Bacterial vaginosis (BV), a clinical condition characterized by decreased vaginal Lactobacillus spp., is difficult to treat. We examined associations between micronutrient intake and a low-Lactobacillus vaginal microbiota as assessed by molecular methods (termed “molecular-BV”). Methods This cross-sectional analysis utilized data collected at the baseline visit of the Hormonal Contraception Longitudinal Study, a cohort of reproductive-aged women followed over 2 years while initiating or ceasing hormonal contraception (HC). The Block Brief 2000 Food Frequency Questionnaire was administered and micronutrient intakes were ranked. Vaginal microbiota composition was assessed using 16S rRNA gene amplicon sequencing and clustered into community state types (CSTs) based on the types and relative abundance of bacteria detected. Associations between the lowest estimated quartile intake of nutrients and having a low-Lactobacillus CST (molecular-BV) were evaluated by logistic regression. Separate models were built for each nutrient controlling for age, body mass index, behavioral factors, HC use and total energy intake. We also conducted a literature review of existing data on associations between micronutrient intakes and BV. Results Samples from 104 women were included in this analysis. Their mean age was 25.8 years (SD 4.3), 29.8% were African American, 48.1% were using HC, and 25% had molecular-BV. In adjusted multivariable analyses, the lowest quartile of betaine intake was associated with an increased odds of molecular-BV (aOR 9.2, p value < 0.01, [CI 2.4–35.0]). Conclusions This is the first study to assess the association between estimated micronutrient intake and molecular-BV. Lower energy-adjusted intake of betaine was associated with an increased risk of molecular-BV. Betaine might have direct effects on the vaginal microenvironment or may be mediated through the gut microbiota. Additional research is needed to determine reproducibility of this finding and whether improved intake of select micronutrients such as betaine decreases the risk of BV and its sequelae.http://link.springer.com/article/10.1186/s12978-019-0814-6Bacterial VaginosisVaginal microbiomeBetaineFood frequency questionnaire |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Susan Tuddenham Khalil G. Ghanem Laura E. Caulfield Alisha J. Rovner Courtney Robinson Rupak Shivakoti Ryan Miller Anne Burke Catherine Murphy Jacques Ravel Rebecca M. Brotman |
spellingShingle |
Susan Tuddenham Khalil G. Ghanem Laura E. Caulfield Alisha J. Rovner Courtney Robinson Rupak Shivakoti Ryan Miller Anne Burke Catherine Murphy Jacques Ravel Rebecca M. Brotman Associations between dietary micronutrient intake and molecular-Bacterial Vaginosis Reproductive Health Bacterial Vaginosis Vaginal microbiome Betaine Food frequency questionnaire |
author_facet |
Susan Tuddenham Khalil G. Ghanem Laura E. Caulfield Alisha J. Rovner Courtney Robinson Rupak Shivakoti Ryan Miller Anne Burke Catherine Murphy Jacques Ravel Rebecca M. Brotman |
author_sort |
Susan Tuddenham |
title |
Associations between dietary micronutrient intake and molecular-Bacterial Vaginosis |
title_short |
Associations between dietary micronutrient intake and molecular-Bacterial Vaginosis |
title_full |
Associations between dietary micronutrient intake and molecular-Bacterial Vaginosis |
title_fullStr |
Associations between dietary micronutrient intake and molecular-Bacterial Vaginosis |
title_full_unstemmed |
Associations between dietary micronutrient intake and molecular-Bacterial Vaginosis |
title_sort |
associations between dietary micronutrient intake and molecular-bacterial vaginosis |
publisher |
BMC |
series |
Reproductive Health |
issn |
1742-4755 |
publishDate |
2019-10-01 |
description |
Abstract Objectives Bacterial vaginosis (BV), a clinical condition characterized by decreased vaginal Lactobacillus spp., is difficult to treat. We examined associations between micronutrient intake and a low-Lactobacillus vaginal microbiota as assessed by molecular methods (termed “molecular-BV”). Methods This cross-sectional analysis utilized data collected at the baseline visit of the Hormonal Contraception Longitudinal Study, a cohort of reproductive-aged women followed over 2 years while initiating or ceasing hormonal contraception (HC). The Block Brief 2000 Food Frequency Questionnaire was administered and micronutrient intakes were ranked. Vaginal microbiota composition was assessed using 16S rRNA gene amplicon sequencing and clustered into community state types (CSTs) based on the types and relative abundance of bacteria detected. Associations between the lowest estimated quartile intake of nutrients and having a low-Lactobacillus CST (molecular-BV) were evaluated by logistic regression. Separate models were built for each nutrient controlling for age, body mass index, behavioral factors, HC use and total energy intake. We also conducted a literature review of existing data on associations between micronutrient intakes and BV. Results Samples from 104 women were included in this analysis. Their mean age was 25.8 years (SD 4.3), 29.8% were African American, 48.1% were using HC, and 25% had molecular-BV. In adjusted multivariable analyses, the lowest quartile of betaine intake was associated with an increased odds of molecular-BV (aOR 9.2, p value < 0.01, [CI 2.4–35.0]). Conclusions This is the first study to assess the association between estimated micronutrient intake and molecular-BV. Lower energy-adjusted intake of betaine was associated with an increased risk of molecular-BV. Betaine might have direct effects on the vaginal microenvironment or may be mediated through the gut microbiota. Additional research is needed to determine reproducibility of this finding and whether improved intake of select micronutrients such as betaine decreases the risk of BV and its sequelae. |
topic |
Bacterial Vaginosis Vaginal microbiome Betaine Food frequency questionnaire |
url |
http://link.springer.com/article/10.1186/s12978-019-0814-6 |
work_keys_str_mv |
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