In Vivo and In Vitro Anti-Tumor Effects of Fungal Extracts
Fungal extracts are extensively used as nutritional supplements in Far-Eastern Asia. In this study, we aimed to evaluate the anti-cancer activities of some different fungal species against different cancer cell lines. The water or ethanol extracts of Fomitopsis pinicola (F. pinicola), Ganoderma sin...
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doaj-bcdbf4b526f7406b940c695904e8520d2020-11-25T01:05:13ZengMDPI AGMolecules1420-30492014-02-011922546255610.3390/molecules19022546molecules19022546In Vivo and In Vitro Anti-Tumor Effects of Fungal ExtractsHung-Tsung Wu0Feng-Hwa Lu1Yu-Chu Su2Horng-Yih Ou3Hao-Chang Hung4Jin-Shang Wu5Yi-Ching Yang6Chih-Jen Chang7Research Center of Herbal Medicine, New Drugs and Nutritional Supplements, Research and Services Headquarters, National Cheng Kung University, Tainan 70403, TaiwanDepartment of Family Medicine, National Cheng Kung University Medical College and Hospital, Tainan 70403, TaiwanInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70403, TaiwanDepartment of Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan 70403, TaiwanDepartment of Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan 70403, TaiwanDepartment of Family Medicine, National Cheng Kung University Medical College and Hospital, Tainan 70403, TaiwanDepartment of Family Medicine, National Cheng Kung University Medical College and Hospital, Tainan 70403, TaiwanResearch Center of Herbal Medicine, New Drugs and Nutritional Supplements, Research and Services Headquarters, National Cheng Kung University, Tainan 70403, TaiwanFungal extracts are extensively used as nutritional supplements in Far-Eastern Asia. In this study, we aimed to evaluate the anti-cancer activities of some different fungal species against different cancer cell lines. The water or ethanol extracts of Fomitopsis pinicola (F. pinicola), Ganoderma sinense, Fomitopsis officinalis, Polyporus melanopus, and Taiwanofungus camphorates were used to evaluate the anti-cancer activities in various cancer cells. We found that all of the fungi ethanol extracts used in this study exert anti-cancer activities in vitro, whereas water extracts show lower inhibitory activities as determined by 3-(4,5-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Among the tested fungi species, F. pinicola ethanol extract exerts the most significant anti-cancer activity (growth inhibitory ratio 82.8%, p < 0.001) by increasing cell apoptosis. Moreover, F. pinicola ethanol extract significantly decreased tumor size (tumor growth inhibitory ratio 54%, p < 0.05) and increased the lifespan in mice bearing sarcoma-180 tumors. Taken together, this is the first study indicating the anti-tumor effect of F. pinicola in vivo and in vitro. F. pinicola ethanol extract induces cell apoptosis to exert a significant anti-tumor activity, with potential to be a new alternative anti-tumor medicine.http://www.mdpi.com/1420-3049/19/2/2546apoptosiscancerF. pinicolasarcoma-180 cellstumors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hung-Tsung Wu Feng-Hwa Lu Yu-Chu Su Horng-Yih Ou Hao-Chang Hung Jin-Shang Wu Yi-Ching Yang Chih-Jen Chang |
spellingShingle |
Hung-Tsung Wu Feng-Hwa Lu Yu-Chu Su Horng-Yih Ou Hao-Chang Hung Jin-Shang Wu Yi-Ching Yang Chih-Jen Chang In Vivo and In Vitro Anti-Tumor Effects of Fungal Extracts Molecules apoptosis cancer F. pinicola sarcoma-180 cells tumors |
author_facet |
Hung-Tsung Wu Feng-Hwa Lu Yu-Chu Su Horng-Yih Ou Hao-Chang Hung Jin-Shang Wu Yi-Ching Yang Chih-Jen Chang |
author_sort |
Hung-Tsung Wu |
title |
In Vivo and In Vitro Anti-Tumor Effects of Fungal Extracts |
title_short |
In Vivo and In Vitro Anti-Tumor Effects of Fungal Extracts |
title_full |
In Vivo and In Vitro Anti-Tumor Effects of Fungal Extracts |
title_fullStr |
In Vivo and In Vitro Anti-Tumor Effects of Fungal Extracts |
title_full_unstemmed |
In Vivo and In Vitro Anti-Tumor Effects of Fungal Extracts |
title_sort |
in vivo and in vitro anti-tumor effects of fungal extracts |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2014-02-01 |
description |
Fungal extracts are extensively used as nutritional supplements in Far-Eastern Asia. In this study, we aimed to evaluate the anti-cancer activities of some different fungal species against different cancer cell lines. The water or ethanol extracts of Fomitopsis pinicola (F. pinicola), Ganoderma sinense, Fomitopsis officinalis, Polyporus melanopus, and Taiwanofungus camphorates were used to evaluate the anti-cancer activities in various cancer cells. We found that all of the fungi ethanol extracts used in this study exert anti-cancer activities in vitro, whereas water extracts show lower inhibitory activities as determined by 3-(4,5-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Among the tested fungi species, F. pinicola ethanol extract exerts the most significant anti-cancer activity (growth inhibitory ratio 82.8%, p < 0.001) by increasing cell apoptosis. Moreover, F. pinicola ethanol extract significantly decreased tumor size (tumor growth inhibitory ratio 54%, p < 0.05) and increased the lifespan in mice bearing sarcoma-180 tumors. Taken together, this is the first study indicating the anti-tumor effect of F. pinicola in vivo and in vitro. F. pinicola ethanol extract induces cell apoptosis to exert a significant anti-tumor activity, with potential to be a new alternative anti-tumor medicine. |
topic |
apoptosis cancer F. pinicola sarcoma-180 cells tumors |
url |
http://www.mdpi.com/1420-3049/19/2/2546 |
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