Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity
Stenochlaena palustris fronds are popular as a vegetable in Southeast Asia. The objectives of this study were to evaluate the anticholinesterase properties and phytochemical profiles of the young and mature fronds of this plant. Both types of fronds were found to have selective inhibitory effect aga...
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doaj-bce290c95be5406ca3982bef67be461e2020-11-24T23:11:27ZengElsevierJournal of Food and Drug Analysis1021-94982016-04-0124235836610.1016/j.jfda.2015.12.005Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturityNelson Jeng-Yeou Chear0Kooi-Yeong Khaw1Vikneswaran Murugaiyah2Choon-Sheen Lai3Centre for Drug Research, Universiti Sains Malaysia, Penang, MalaysiaSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, MalaysiaSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, MalaysiaCentre for Drug Research, Universiti Sains Malaysia, Penang, MalaysiaStenochlaena palustris fronds are popular as a vegetable in Southeast Asia. The objectives of this study were to evaluate the anticholinesterase properties and phytochemical profiles of the young and mature fronds of this plant. Both types of fronds were found to have selective inhibitory effect against butyrylcholinesterase compared with acetylcholinesterase. However, different sets of compounds were responsible for their activity. In young fronds, an antibutyrylcholinesterase effect was observed in the hexane extract, which was comprised of a variety of aliphatic hydrocarbons, fatty acids, and phytosterols. In the mature fronds, inhibitory activity was observed in the methanol extract, which contained a series of kaempferol glycosides. Our results provided novel information concerning the ability of S. palustris to inhibit cholinesterase and its phytochemical profile. Further research to investigate the potential use of this plant against Alzheimer's disease is warranted, however, young and mature fronds should be distinguished due to their phytochemical differences.http://www.sciencedirect.com/science/article/pii/S1021949816000144anticholinesteraseStenochlaena palustrisBlechnaceaephytochemical profilefrond maturity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nelson Jeng-Yeou Chear Kooi-Yeong Khaw Vikneswaran Murugaiyah Choon-Sheen Lai |
spellingShingle |
Nelson Jeng-Yeou Chear Kooi-Yeong Khaw Vikneswaran Murugaiyah Choon-Sheen Lai Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity Journal of Food and Drug Analysis anticholinesterase Stenochlaena palustris Blechnaceae phytochemical profile frond maturity |
author_facet |
Nelson Jeng-Yeou Chear Kooi-Yeong Khaw Vikneswaran Murugaiyah Choon-Sheen Lai |
author_sort |
Nelson Jeng-Yeou Chear |
title |
Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity |
title_short |
Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity |
title_full |
Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity |
title_fullStr |
Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity |
title_full_unstemmed |
Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity |
title_sort |
cholinesterase inhibitory activity and chemical constituents of stenochlaena palustris fronds at two different stages of maturity |
publisher |
Elsevier |
series |
Journal of Food and Drug Analysis |
issn |
1021-9498 |
publishDate |
2016-04-01 |
description |
Stenochlaena palustris fronds are popular as a vegetable in Southeast Asia. The objectives of this study were to evaluate the anticholinesterase properties and phytochemical profiles of the young and mature fronds of this plant. Both types of fronds were found to have selective inhibitory effect against butyrylcholinesterase compared with acetylcholinesterase. However, different sets of compounds were responsible for their activity. In young fronds, an antibutyrylcholinesterase effect was observed in the hexane extract, which was comprised of a variety of aliphatic hydrocarbons, fatty acids, and phytosterols. In the mature fronds, inhibitory activity was observed in the methanol extract, which contained a series of kaempferol glycosides. Our results provided novel information concerning the ability of S. palustris to inhibit cholinesterase and its phytochemical profile. Further research to investigate the potential use of this plant against Alzheimer's disease is warranted, however, young and mature fronds should be distinguished due to their phytochemical differences. |
topic |
anticholinesterase Stenochlaena palustris Blechnaceae phytochemical profile frond maturity |
url |
http://www.sciencedirect.com/science/article/pii/S1021949816000144 |
work_keys_str_mv |
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