Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina
Regeneration responses in animals are widespread across phyla. To identify molecular players that confer regenerative capacities to non-regenerative species is of key relevance for basic research and translational approaches. Here, we report a differential response in retinal regeneration between me...
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doaj-bce6cb71c2094102b4298a628554278d2021-05-05T15:33:20ZengeLife Sciences Publications LtdeLife2050-084X2018-01-01710.7554/eLife.32319Activating the regenerative potential of Müller glia cells in a regeneration-deficient retinaKatharina Lust0https://orcid.org/0000-0002-2580-5492Joachim Wittbrodt1https://orcid.org/0000-0001-8550-7377Centre for Organismal Studies, Heidelberg University, Heidelberg, Germany; Hartmut Hoffmann-Berling International Graduate School, Heidelberg, GermanyCentre for Organismal Studies, Heidelberg University, Heidelberg, GermanyRegeneration responses in animals are widespread across phyla. To identify molecular players that confer regenerative capacities to non-regenerative species is of key relevance for basic research and translational approaches. Here, we report a differential response in retinal regeneration between medaka (Oryzias latipes) and zebrafish (Danio rerio). In contrast to zebrafish, medaka Müller glia (olMG) cells behave like progenitors and exhibit a restricted capacity to regenerate the retina. After injury, olMG cells proliferate but fail to self-renew and ultimately only restore photoreceptors. In our injury paradigm, we observed that in contrast to zebrafish, proliferating olMG cells do not maintain sox2 expression. Sustained sox2 expression in olMG cells confers regenerative responses similar to those of zebrafish MG (drMG) cells. We show that a single, cell-autonomous factor reprograms olMG cells and establishes a regeneration-like mode. Our results position medaka as an attractive model to delineate key regeneration factors with translational potential.https://elifesciences.org/articles/32319Müller glia cellsretina regenerationSox2in vivo imaginglineage tracingmedaka |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katharina Lust Joachim Wittbrodt |
spellingShingle |
Katharina Lust Joachim Wittbrodt Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina eLife Müller glia cells retina regeneration Sox2 in vivo imaging lineage tracing medaka |
author_facet |
Katharina Lust Joachim Wittbrodt |
author_sort |
Katharina Lust |
title |
Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina |
title_short |
Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina |
title_full |
Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina |
title_fullStr |
Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina |
title_full_unstemmed |
Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina |
title_sort |
activating the regenerative potential of müller glia cells in a regeneration-deficient retina |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2018-01-01 |
description |
Regeneration responses in animals are widespread across phyla. To identify molecular players that confer regenerative capacities to non-regenerative species is of key relevance for basic research and translational approaches. Here, we report a differential response in retinal regeneration between medaka (Oryzias latipes) and zebrafish (Danio rerio). In contrast to zebrafish, medaka Müller glia (olMG) cells behave like progenitors and exhibit a restricted capacity to regenerate the retina. After injury, olMG cells proliferate but fail to self-renew and ultimately only restore photoreceptors. In our injury paradigm, we observed that in contrast to zebrafish, proliferating olMG cells do not maintain sox2 expression. Sustained sox2 expression in olMG cells confers regenerative responses similar to those of zebrafish MG (drMG) cells. We show that a single, cell-autonomous factor reprograms olMG cells and establishes a regeneration-like mode. Our results position medaka as an attractive model to delineate key regeneration factors with translational potential. |
topic |
Müller glia cells retina regeneration Sox2 in vivo imaging lineage tracing medaka |
url |
https://elifesciences.org/articles/32319 |
work_keys_str_mv |
AT katharinalust activatingtheregenerativepotentialofmullergliacellsinaregenerationdeficientretina AT joachimwittbrodt activatingtheregenerativepotentialofmullergliacellsinaregenerationdeficientretina |
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1721459945825632256 |