Nimotuzumab for Patients With Inoperable Cancer of the Head and Neck
EGFR activation induces cell proliferation, neoformation of blood vessels, survival, and metastasis of the cancer cells. Nimotuzumab is an engineered, intermediate affinity anti-EGFR antibody, that apart from other drugs in its class, is very safe and does not cause hypomagnesemia or grade 3–4 cutan...
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doaj-bceb0de3d3f9425f805305ce0060dcf02020-11-25T03:23:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-05-011010.3389/fonc.2020.00817513895Nimotuzumab for Patients With Inoperable Cancer of the Head and NeckTania Crombet Ramos0Braulio Mestre Fernández1Zaima Mazorra Herrera2Normando E. Iznaga Escobar3Center of Molecular Immunology, Havana, CubaClinical Oncology, National Institute of Oncology and Radiobiology, Havana, CubaCenter of Molecular Immunology, Havana, CubaBiocubafarma, Havana, CubaEGFR activation induces cell proliferation, neoformation of blood vessels, survival, and metastasis of the cancer cells. Nimotuzumab is an engineered, intermediate affinity anti-EGFR antibody, that apart from other drugs in its class, is very safe and does not cause hypomagnesemia or grade 3–4 cutaneous rash. The antibody inhibits cell proliferation and angiogenesis, activates natural killer cells, stimulates dendritic cell maturation, and induces cytotoxic T cells. Nimotuzumab restores MHC-I expression on tumor cells, hindering one of the EGFR immune-escape ways. The antibody has been extensively studied in 7 clinical trials, concurrently with irradiation or irradiation plus chemotherapy in subjects with inoperable head and neck tumors. Nimotuzumab was safe and efficacious in unfit patients receiving irradiation alone and in subjects treated with cisplatin and radiotherapy. In patients with locally advanced squamous cell carcinomas of the head and neck, nimotuzumab in combination with low dose cisplatin and radiotherapy was superior to cisplatin and radiotherapy in progression free survival, disease free survival, and locoregional tumor control.https://www.frontiersin.org/article/10.3389/fonc.2020.00817/fullnimotuzumabEGFRmonoclonal antibodyhead and neckradiotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tania Crombet Ramos Braulio Mestre Fernández Zaima Mazorra Herrera Normando E. Iznaga Escobar |
spellingShingle |
Tania Crombet Ramos Braulio Mestre Fernández Zaima Mazorra Herrera Normando E. Iznaga Escobar Nimotuzumab for Patients With Inoperable Cancer of the Head and Neck Frontiers in Oncology nimotuzumab EGFR monoclonal antibody head and neck radiotherapy |
author_facet |
Tania Crombet Ramos Braulio Mestre Fernández Zaima Mazorra Herrera Normando E. Iznaga Escobar |
author_sort |
Tania Crombet Ramos |
title |
Nimotuzumab for Patients With Inoperable Cancer of the Head and Neck |
title_short |
Nimotuzumab for Patients With Inoperable Cancer of the Head and Neck |
title_full |
Nimotuzumab for Patients With Inoperable Cancer of the Head and Neck |
title_fullStr |
Nimotuzumab for Patients With Inoperable Cancer of the Head and Neck |
title_full_unstemmed |
Nimotuzumab for Patients With Inoperable Cancer of the Head and Neck |
title_sort |
nimotuzumab for patients with inoperable cancer of the head and neck |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-05-01 |
description |
EGFR activation induces cell proliferation, neoformation of blood vessels, survival, and metastasis of the cancer cells. Nimotuzumab is an engineered, intermediate affinity anti-EGFR antibody, that apart from other drugs in its class, is very safe and does not cause hypomagnesemia or grade 3–4 cutaneous rash. The antibody inhibits cell proliferation and angiogenesis, activates natural killer cells, stimulates dendritic cell maturation, and induces cytotoxic T cells. Nimotuzumab restores MHC-I expression on tumor cells, hindering one of the EGFR immune-escape ways. The antibody has been extensively studied in 7 clinical trials, concurrently with irradiation or irradiation plus chemotherapy in subjects with inoperable head and neck tumors. Nimotuzumab was safe and efficacious in unfit patients receiving irradiation alone and in subjects treated with cisplatin and radiotherapy. In patients with locally advanced squamous cell carcinomas of the head and neck, nimotuzumab in combination with low dose cisplatin and radiotherapy was superior to cisplatin and radiotherapy in progression free survival, disease free survival, and locoregional tumor control. |
topic |
nimotuzumab EGFR monoclonal antibody head and neck radiotherapy |
url |
https://www.frontiersin.org/article/10.3389/fonc.2020.00817/full |
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