RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma

RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma

Abstract Background Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor regression in several clinical trials. However, genetically engineered T cells have been associated with serious side-...

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Bibliographic Details
Main Authors: Dennis C. Harrer, Bianca Simon, Shin-ichiro Fujii, Kanako Shimizu, Ugur Uslu, Gerold Schuler, Kerstin F. Gerer, Stefanie Hoyer, Jan Dörrie, Niels Schaft
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Cancer
Subjects:
Immune evasion
Cross-reaction
MHC-downregulation
γ/δ T cell
Adoptive T-cell therapy
Chimeric antigen receptor
Online Access:http://link.springer.com/article/10.1186/s12885-017-3539-3

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