Frequency of Toxocara Antibodies in Patients Clinically Suspected to Ocular Toxocariasis, Northeast of Iran
Background: Human toxocariasis is a neglected parasitic disease in most countries including Iran. Among different clinical forms of toxocariasis, ocular toxocariasis (OT) is an important disease resulting in severe vision loss. However, the prevalence and incidence of OT are currently unclear in Ir...
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doaj-bcff1edc62044dc0bdaafeaf48f74d7e2021-09-11T05:05:04ZengTehran University of Medical SciencesIranian Journal of Parasitology1735-70202008-238X2021-05-0116210.18502/ijpa.v16i2.63122435Frequency of Toxocara Antibodies in Patients Clinically Suspected to Ocular Toxocariasis, Northeast of IranAbdolmajid Fata0Seyedeh Maryam Hosseini1Se Joon Woo2Mohammad Zibaei3Fariba Berenji4Bibi Razieh Hosseini Farash5Elham Moghaddas6Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 2. Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, IranEye Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, KoreaDepartment of Parasitology and Mycology, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, IranDepartment of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran1. Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 2. Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Background: Human toxocariasis is a neglected parasitic disease in most countries including Iran. Among different clinical forms of toxocariasis, ocular toxocariasis (OT) is an important disease resulting in severe vision loss. However, the prevalence and incidence of OT are currently unclear in Iran. This study aimed to determine the prevalence of ocular toxocariasis among patients with uveitis in the Northeast of Iran. Methods: From 2015 to 2017, 510 patients with uveitis referred to Khatam-al-Anbia, a tertiary eye hospital at Mashhad, Iran were examined for OT. Serum samples of the suspected patients were obtained and evaluated for IgG against Toxocara canis using ELISA test. Anti-Toxocara IgG positive serums were further investigated using confirmatory Western blotting (WB) analysis. Results: Twenty patients had pathologic changes and clinical presentations in the anterior and posterior segments of their eyes and they were clinically diagnosed ocular toxocariasis. Among the 20 patients, 2 (10%) patients showed IgG antibody against Toxocara canis on ELISA as well as on WB test. The calculated prevalence of ocular toxocariasis was about 0.4%. Conclusion: Ocular toxocariasis can be diagnosed both clinically and serologically in Mashhad, northeastern Iran. Although OT is a rare pathologic eye disease, it should be considered as one of the important cause of infectious posterior uveitis. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/2435ToxocariasisUveitisWestern blotting |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abdolmajid Fata Seyedeh Maryam Hosseini Se Joon Woo Mohammad Zibaei Fariba Berenji Bibi Razieh Hosseini Farash Elham Moghaddas |
spellingShingle |
Abdolmajid Fata Seyedeh Maryam Hosseini Se Joon Woo Mohammad Zibaei Fariba Berenji Bibi Razieh Hosseini Farash Elham Moghaddas Frequency of Toxocara Antibodies in Patients Clinically Suspected to Ocular Toxocariasis, Northeast of Iran Iranian Journal of Parasitology Toxocariasis Uveitis Western blotting |
author_facet |
Abdolmajid Fata Seyedeh Maryam Hosseini Se Joon Woo Mohammad Zibaei Fariba Berenji Bibi Razieh Hosseini Farash Elham Moghaddas |
author_sort |
Abdolmajid Fata |
title |
Frequency of Toxocara Antibodies in Patients Clinically Suspected to Ocular Toxocariasis, Northeast of Iran |
title_short |
Frequency of Toxocara Antibodies in Patients Clinically Suspected to Ocular Toxocariasis, Northeast of Iran |
title_full |
Frequency of Toxocara Antibodies in Patients Clinically Suspected to Ocular Toxocariasis, Northeast of Iran |
title_fullStr |
Frequency of Toxocara Antibodies in Patients Clinically Suspected to Ocular Toxocariasis, Northeast of Iran |
title_full_unstemmed |
Frequency of Toxocara Antibodies in Patients Clinically Suspected to Ocular Toxocariasis, Northeast of Iran |
title_sort |
frequency of toxocara antibodies in patients clinically suspected to ocular toxocariasis, northeast of iran |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Parasitology |
issn |
1735-7020 2008-238X |
publishDate |
2021-05-01 |
description |
Background: Human toxocariasis is a neglected parasitic disease in most countries including Iran. Among different clinical forms of toxocariasis, ocular toxocariasis (OT) is an important disease resulting in severe vision loss. However, the prevalence and incidence of OT are currently unclear in Iran. This study aimed to determine the prevalence of ocular toxocariasis among patients with uveitis in the Northeast of Iran.
Methods: From 2015 to 2017, 510 patients with uveitis referred to Khatam-al-Anbia, a tertiary eye hospital at Mashhad, Iran were examined for OT. Serum samples of the suspected patients were obtained and evaluated for IgG against Toxocara canis using ELISA test. Anti-Toxocara IgG positive serums were further investigated using confirmatory Western blotting (WB) analysis.
Results: Twenty patients had pathologic changes and clinical presentations in the anterior and posterior segments of their eyes and they were clinically diagnosed ocular toxocariasis. Among the 20 patients, 2 (10%) patients showed IgG antibody against Toxocara canis on ELISA as well as on WB test. The calculated prevalence of ocular toxocariasis was about 0.4%.
Conclusion: Ocular toxocariasis can be diagnosed both clinically and serologically in Mashhad, northeastern Iran. Although OT is a rare pathologic eye disease, it should be considered as one of the important cause of infectious posterior uveitis.
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topic |
Toxocariasis Uveitis Western blotting |
url |
https://ijpa.tums.ac.ir/index.php/ijpa/article/view/2435 |
work_keys_str_mv |
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