Regulatory mechanisms of incomplete huntingtin mRNA splicing
Incomplete splicing of HTT results in the production of the highly pathogenic exon 1 HTT protein. Here the authors identify the necessary intronic regions and the underlying mechanisms that contribute to this process.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06281-3 |
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doaj-bd15556f976d414a8586ab29954b52a82021-05-11T09:46:33ZengNature Publishing GroupNature Communications2041-17232018-09-019111310.1038/s41467-018-06281-3Regulatory mechanisms of incomplete huntingtin mRNA splicingAndreas Neueder0Anaelle A. Dumas1Agnesska C. Benjamin2Gillian P. Bates3UCL Huntington’s Disease Centre, Department of Neurodegenerative Disease and Dementia Research Institute, UCL Institute of Neurology, University College LondonUCL Huntington’s Disease Centre, Department of Neurodegenerative Disease and Dementia Research Institute, UCL Institute of Neurology, University College LondonUCL Huntington’s Disease Centre, Department of Neurodegenerative Disease and Dementia Research Institute, UCL Institute of Neurology, University College LondonUCL Huntington’s Disease Centre, Department of Neurodegenerative Disease and Dementia Research Institute, UCL Institute of Neurology, University College LondonIncomplete splicing of HTT results in the production of the highly pathogenic exon 1 HTT protein. Here the authors identify the necessary intronic regions and the underlying mechanisms that contribute to this process.https://doi.org/10.1038/s41467-018-06281-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Andreas Neueder Anaelle A. Dumas Agnesska C. Benjamin Gillian P. Bates |
| spellingShingle |
Andreas Neueder Anaelle A. Dumas Agnesska C. Benjamin Gillian P. Bates Regulatory mechanisms of incomplete huntingtin mRNA splicing Nature Communications |
| author_facet |
Andreas Neueder Anaelle A. Dumas Agnesska C. Benjamin Gillian P. Bates |
| author_sort |
Andreas Neueder |
| title |
Regulatory mechanisms of incomplete huntingtin mRNA splicing |
| title_short |
Regulatory mechanisms of incomplete huntingtin mRNA splicing |
| title_full |
Regulatory mechanisms of incomplete huntingtin mRNA splicing |
| title_fullStr |
Regulatory mechanisms of incomplete huntingtin mRNA splicing |
| title_full_unstemmed |
Regulatory mechanisms of incomplete huntingtin mRNA splicing |
| title_sort |
regulatory mechanisms of incomplete huntingtin mrna splicing |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-09-01 |
| description |
Incomplete splicing of HTT results in the production of the highly pathogenic exon 1 HTT protein. Here the authors identify the necessary intronic regions and the underlying mechanisms that contribute to this process. |
| url |
https://doi.org/10.1038/s41467-018-06281-3 |
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