Estimating and comparing microbial diversity in the presence of sequencing errors

Estimating and comparing microbial diversity are statistically challenging due to limited sampling and possible sequencing errors for low-frequency counts, producing spurious singletons. The inflated singleton count seriously affects statistical analysis and inferences about microbial diversity. Pre...

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Bibliographic Details
Main Authors: Chun-Huo Chiu, Anne Chao
Format: Article
Language:English
Published: PeerJ Inc. 2016-02-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/1634.pdf