Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging

Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging

<p>Abstract</p> <p>Mesencephalic dopamine (DA) projections are essential for cognitive and behavioral functions and believed to play a critical role during development and aging. The dopaminergic afferents of the rodent prefrontal cortex (PFC) show an extremely prolonged maturation...

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Main Authors: Teuchert-Noodt Gertraud, Brummelte Susanne
Format: Article
Language:English
Published: BMC 2007-03-01
Series:Behavioral and Brain Functions
Online Access:http://www.behavioralandbrainfunctions.com/content/3/1/14
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spelling doaj-bd1fe87796c34ca29c1c79eca3e8438d2020-11-25T01:03:49ZengBMCBehavioral and Brain Functions1744-90812007-03-01311410.1186/1744-9081-3-14Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to agingTeuchert-Noodt GertraudBrummelte Susanne<p>Abstract</p> <p>Mesencephalic dopamine (DA) projections are essential for cognitive and behavioral functions and believed to play a critical role during development and aging. The dopaminergic afferents of the rodent prefrontal cortex (PFC) show an extremely prolonged maturation which is very sensitive to epigenetic challenges. However, less is known about the long-term maturation and aging of these DA axons. Therefore, immunohistochemically stained DA fibres were quantitatively examined in the PFC of the Mongolian gerbil (<it>Meriones unguiculatus</it>) ranging from 6 to 24 months of age. Results show a decrease in DA fibre densities in the superficial layers of the PFC in 24 month old animals compared to 6 and 12 months.</p> http://www.behavioralandbrainfunctions.com/content/3/1/14
collection DOAJ
language English
format Article
sources DOAJ
author Teuchert-Noodt Gertraud
Brummelte Susanne
spellingShingle Teuchert-Noodt Gertraud
Brummelte Susanne
Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
Behavioral and Brain Functions
author_facet Teuchert-Noodt Gertraud
Brummelte Susanne
author_sort Teuchert-Noodt Gertraud
title Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
title_short Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
title_full Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
title_fullStr Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
title_full_unstemmed Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
title_sort density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
publisher BMC
series Behavioral and Brain Functions
issn 1744-9081
publishDate 2007-03-01
description <p>Abstract</p> <p>Mesencephalic dopamine (DA) projections are essential for cognitive and behavioral functions and believed to play a critical role during development and aging. The dopaminergic afferents of the rodent prefrontal cortex (PFC) show an extremely prolonged maturation which is very sensitive to epigenetic challenges. However, less is known about the long-term maturation and aging of these DA axons. Therefore, immunohistochemically stained DA fibres were quantitatively examined in the PFC of the Mongolian gerbil (<it>Meriones unguiculatus</it>) ranging from 6 to 24 months of age. Results show a decrease in DA fibre densities in the superficial layers of the PFC in 24 month old animals compared to 6 and 12 months.</p>
url http://www.behavioralandbrainfunctions.com/content/3/1/14
work_keys_str_mv AT teuchertnoodtgertraud densityofdopaminergicfibresintheprefrontalcortexofgerbilsissensitivetoaging
AT brummeltesusanne densityofdopaminergicfibresintheprefrontalcortexofgerbilsissensitivetoaging
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