Anti-Inflammatory Effect of Sulforaphane on LPS-Activated Microglia Potentially through JNK/AP-1/NF-κB Inhibition and Nrf2/HO-1 Activation

Anti-Inflammatory Effect of Sulforaphane on LPS-Activated Microglia Potentially through JNK/AP-1/NF-κB Inhibition and Nrf2/HO-1 Activation

Sulforaphane (SFN), a potent nuclear factor erythroid 2-related factor 2 (Nrf2) activator, is present in the species of the Brassicaceae, especially in broccoli sprouts. In this study, the effects of SFN against microglial activation and inflammation, and the potential mechanisms involved, were anal...

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Bibliographic Details
Main Authors: Lalita Subedi, Jae Hyuk Lee, Silvia Yumnam, Eunhee Ji, Sun Yeou Kim
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cells
Subjects:
neuroinflammation
microglial activation
sulforaphane
pre-treatment
post-treatment
Online Access:https://www.mdpi.com/2073-4409/8/2/194

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