Pedunculopontine arousal system physiology – Implications for insomnia
We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activit...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Brazilian Association of Sleep and Latin American Federation of Sleep Societies
2015-04-01
|
Series: | Sleep Science |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S198400631500036X |
id |
doaj-bd20ebc489b54dbeaef058cffc686432 |
---|---|
record_format |
Article |
spelling |
doaj-bd20ebc489b54dbeaef058cffc6864322020-11-24T22:57:08ZengBrazilian Association of Sleep and Latin American Federation of Sleep Societies Sleep Science1984-00632015-04-0182929910.1016/j.slsci.2015.06.002Pedunculopontine arousal system physiology – Implications for insomniaEdgar Garcia-Rill0Brennon Luster1Susan Mahaffey2Veronica Bisagno3Francisco J. Urbano4Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USACenter for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USACenter for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USAIFIBYNE-CONICET and ININFA-CONICET, University of Buenos Aires, ArgentinaIFIBYNE-CONICET and ININFA-CONICET, University of Buenos Aires, ArgentinaWe consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia.http://www.sciencedirect.com/science/article/pii/S198400631500036XCalcium channelsGamma band activityNeuronal calcium sensor proteinN-type calcium channelP/Q-type calcium channel |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Edgar Garcia-Rill Brennon Luster Susan Mahaffey Veronica Bisagno Francisco J. Urbano |
spellingShingle |
Edgar Garcia-Rill Brennon Luster Susan Mahaffey Veronica Bisagno Francisco J. Urbano Pedunculopontine arousal system physiology – Implications for insomnia Sleep Science Calcium channels Gamma band activity Neuronal calcium sensor protein N-type calcium channel P/Q-type calcium channel |
author_facet |
Edgar Garcia-Rill Brennon Luster Susan Mahaffey Veronica Bisagno Francisco J. Urbano |
author_sort |
Edgar Garcia-Rill |
title |
Pedunculopontine arousal system physiology – Implications for insomnia |
title_short |
Pedunculopontine arousal system physiology – Implications for insomnia |
title_full |
Pedunculopontine arousal system physiology – Implications for insomnia |
title_fullStr |
Pedunculopontine arousal system physiology – Implications for insomnia |
title_full_unstemmed |
Pedunculopontine arousal system physiology – Implications for insomnia |
title_sort |
pedunculopontine arousal system physiology – implications for insomnia |
publisher |
Brazilian Association of Sleep and Latin American Federation of Sleep Societies |
series |
Sleep Science |
issn |
1984-0063 |
publishDate |
2015-04-01 |
description |
We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia. |
topic |
Calcium channels Gamma band activity Neuronal calcium sensor protein N-type calcium channel P/Q-type calcium channel |
url |
http://www.sciencedirect.com/science/article/pii/S198400631500036X |
work_keys_str_mv |
AT edgargarciarill pedunculopontinearousalsystemphysiologyimplicationsforinsomnia AT brennonluster pedunculopontinearousalsystemphysiologyimplicationsforinsomnia AT susanmahaffey pedunculopontinearousalsystemphysiologyimplicationsforinsomnia AT veronicabisagno pedunculopontinearousalsystemphysiologyimplicationsforinsomnia AT franciscojurbano pedunculopontinearousalsystemphysiologyimplicationsforinsomnia |
_version_ |
1725651728335896576 |