Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs

Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs

D-Glucosamine hydrochloride (GlcN∙HCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fu...

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Bibliographic Details
Main Authors: Saburo Minami, Yoshiharu Okamoto, Tomohiro Imagawa, Seiji Kurozumi, Yoshimori Takamori, Takeshi Tsuka, Kazuo Azuma, Tomohiro Osaki
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:Marine Drugs
Subjects:
amino acid
dog
glucosamine hydrochloride
metabolomic analyses
Online Access:http://www.mdpi.com/1660-3397/10/8/1873
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spelling doaj-bd2e96acd6c94ceabb5889d54328bd3c2020-11-24T23:39:59ZengMDPI AGMarine Drugs1660-33972012-08-011081873188210.3390/md10081873Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to DogsSaburo MinamiYoshiharu OkamotoTomohiro ImagawaSeiji KurozumiYoshimori TakamoriTakeshi TsukaKazuo AzumaTomohiro OsakiD-Glucosamine hydrochloride (GlcN∙HCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fumarate respiration and elevated plasma levels of lactic acid and alanine were observed after administration. These results suggest that oral administration of GlcN∙HCl induces anaerobic respiration and starvation in cells, and we hypothesize that these conditions promote cartilage regeneration. Further studies are required to evaluate the expression of transforming growth factor-beta (TGF-β).http://www.mdpi.com/1660-3397/10/8/1873amino aciddogglucosamine hydrochloridemetabolomic analyses
collection DOAJ
language English
format Article
sources DOAJ
author Saburo Minami
Yoshiharu Okamoto
Tomohiro Imagawa
Seiji Kurozumi
Yoshimori Takamori
Takeshi Tsuka
Kazuo Azuma
Tomohiro Osaki
spellingShingle Saburo Minami
Yoshiharu Okamoto
Tomohiro Imagawa
Seiji Kurozumi
Yoshimori Takamori
Takeshi Tsuka
Kazuo Azuma
Tomohiro Osaki
Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
Marine Drugs
amino acid
dog
glucosamine hydrochloride
metabolomic analyses
author_facet Saburo Minami
Yoshiharu Okamoto
Tomohiro Imagawa
Seiji Kurozumi
Yoshimori Takamori
Takeshi Tsuka
Kazuo Azuma
Tomohiro Osaki
author_sort Saburo Minami
title Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
title_short Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
title_full Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
title_fullStr Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
title_full_unstemmed Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
title_sort metabolomic analyses of blood plasma after oral administration of d-glucosamine hydrochloride to dogs
publisher MDPI AG
series Marine Drugs
issn 1660-3397
publishDate 2012-08-01
description D-Glucosamine hydrochloride (GlcN∙HCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fumarate respiration and elevated plasma levels of lactic acid and alanine were observed after administration. These results suggest that oral administration of GlcN∙HCl induces anaerobic respiration and starvation in cells, and we hypothesize that these conditions promote cartilage regeneration. Further studies are required to evaluate the expression of transforming growth factor-beta (TGF-β).
topic amino acid
dog
glucosamine hydrochloride
metabolomic analyses
url http://www.mdpi.com/1660-3397/10/8/1873
work_keys_str_mv AT saburominami metabolomicanalysesofbloodplasmaafteroraladministrationofdglucosaminehydrochloridetodogs
AT yoshiharuokamoto metabolomicanalysesofbloodplasmaafteroraladministrationofdglucosaminehydrochloridetodogs
AT tomohiroimagawa metabolomicanalysesofbloodplasmaafteroraladministrationofdglucosaminehydrochloridetodogs
AT seijikurozumi metabolomicanalysesofbloodplasmaafteroraladministrationofdglucosaminehydrochloridetodogs
AT yoshimoritakamori metabolomicanalysesofbloodplasmaafteroraladministrationofdglucosaminehydrochloridetodogs
AT takeshitsuka metabolomicanalysesofbloodplasmaafteroraladministrationofdglucosaminehydrochloridetodogs
AT kazuoazuma metabolomicanalysesofbloodplasmaafteroraladministrationofdglucosaminehydrochloridetodogs
AT tomohiroosaki metabolomicanalysesofbloodplasmaafteroraladministrationofdglucosaminehydrochloridetodogs
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