Altered Membrane Potential and Electrolyte in Sickle Cell Anemia

• Main Authors: JK Nnodim, SC Meludu, CE Dioka, C Onah, UJ Chilaka, PC Obi
• Format: Article
• Language: English
• Published: Krishna Institute of Medical Sciences University 2014-01-01
• Series: Journal of Krishna Institute of Medical Sciences University
• Subjects: Electrolyte; membrane potential; sickle cell anemia
• Online Access: http://www.jkimsu.com/jkimsu-vol3no1/JKIMSU.%20Vol.%203,%20No.%201,%20Jan-June%202014,Page%2070-73.pdf

Aim: This study has been to evaluate the level of membrane potential and electrolyte in sickle cell disease patients. Material and methods: 100 sickle cell patients in steady state ages 5 to 30 years attending General Hospital Owerri were used in the study while 100 normal subjects (HbAA) were used as control. Also 30 HbSS in crisis have been involved. Results: The results obtained showed that the level of membrane potential was significantly lower in sickle cell anemia as compared to the controls. Also, the level of the electrolyte was found significantly decreased in HbSS when compared with HbAA at P<0.05. Conclusion: The membrane potential translates to energy which means that there is less energy in sickle cell disease which is linked to electrolyte imbalance. Hence people with sickle disease should be monitored closely for their electrolytes to avoid crisis.