Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study
Background. Anal canal adenocarcinoma (AA) is an uncommon tumor of the gastrointestinal tract. We seek to provide a detailed description of the incidence, demographics, and outcome of this rare tumor in the United States. Methods. The data on anal canal adenocarcinoma from SEER Program, between 1973...
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doaj-bd4e01b72bf24638bf6ba08b64c092ea2020-11-25T02:36:39ZengHindawi LimitedInternational Journal of Surgical Oncology2090-14022090-14102020-01-01202010.1155/2020/51392365139236Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based StudyShekhar Gogna0Roberto Bergamaschi1Agon Kajmolli2Mahir Gachabayov3Aram Rojas4David Samson5Rifat Latifi6Xiang Da Dong7Division of Surgical Oncology, Westchester Medical Center, New York Medical College, 100 Woods Road, Taylor Pavilion, Office Suite #353, Valhalla, NY 10595, USADivision of Surgical Oncology, Westchester Medical Center, New York Medical College, 100 Woods Road, Taylor Pavilion, Office Suite #353, Valhalla, NY 10595, USADivision of Surgical Oncology, Westchester Medical Center, New York Medical College, 100 Woods Road, Taylor Pavilion, Office Suite #353, Valhalla, NY 10595, USADivision of Surgical Oncology, Westchester Medical Center, New York Medical College, 100 Woods Road, Taylor Pavilion, Office Suite #353, Valhalla, NY 10595, USADivision of Surgical Oncology, Westchester Medical Center, New York Medical College, 100 Woods Road, Taylor Pavilion, Office Suite #353, Valhalla, NY 10595, USADivision of Surgical Oncology, Westchester Medical Center, New York Medical College, 100 Woods Road, Taylor Pavilion, Office Suite #353, Valhalla, NY 10595, USADivision of Surgical Oncology, Westchester Medical Center, New York Medical College, 100 Woods Road, Taylor Pavilion, Office Suite #353, Valhalla, NY 10595, USADivision of Surgical Oncology, Westchester Medical Center, New York Medical College, 100 Woods Road, Taylor Pavilion, Office Suite #353, Valhalla, NY 10595, USABackground. Anal canal adenocarcinoma (AA) is an uncommon tumor of the gastrointestinal tract. We seek to provide a detailed description of the incidence, demographics, and outcome of this rare tumor in the United States. Methods. The data on anal canal adenocarcinoma from SEER Program, between 1973–2015, were extracted. We analyzed the incidence rates by demographics and tumor characteristics, followed by analysis of its impact on survival. Results. The incidence of AA increased initially by 4.03% yearly from 1973 to 1985 but had a modest decline of 0.32% annually thereafter. The mean age for diagnosis of AA was 68.12 ± 14.02 years. Males outnumbered females by 54.8 to 45.2%. Tumors were mostly localized on presentation (44.4%) and moderately differentiated (41.1%). Age generally correlated with poor overall cancer survival. However, young patients (age <40 years) also showed poor long-term survival. Patients with localized disease and well-differentiated tumors showed better survival outcomes. Surgical intervention improved survival significantly as compared to patients who did not (116.7 months vs 42.7 months, p<0.01). Conclusions. Anal canal adenocarcinoma demonstrated a poor bimodal cancer-free survival in both younger and older patient groups. Surgery significantly improves odds of survival and should be offered to patients amenable to intervention.http://dx.doi.org/10.1155/2020/5139236 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shekhar Gogna Roberto Bergamaschi Agon Kajmolli Mahir Gachabayov Aram Rojas David Samson Rifat Latifi Xiang Da Dong |
spellingShingle |
Shekhar Gogna Roberto Bergamaschi Agon Kajmolli Mahir Gachabayov Aram Rojas David Samson Rifat Latifi Xiang Da Dong Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study International Journal of Surgical Oncology |
author_facet |
Shekhar Gogna Roberto Bergamaschi Agon Kajmolli Mahir Gachabayov Aram Rojas David Samson Rifat Latifi Xiang Da Dong |
author_sort |
Shekhar Gogna |
title |
Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study |
title_short |
Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study |
title_full |
Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study |
title_fullStr |
Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study |
title_full_unstemmed |
Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study |
title_sort |
clinicopathologic features and outcome of adenocarcinoma of the anal canal: a population-based study |
publisher |
Hindawi Limited |
series |
International Journal of Surgical Oncology |
issn |
2090-1402 2090-1410 |
publishDate |
2020-01-01 |
description |
Background. Anal canal adenocarcinoma (AA) is an uncommon tumor of the gastrointestinal tract. We seek to provide a detailed description of the incidence, demographics, and outcome of this rare tumor in the United States. Methods. The data on anal canal adenocarcinoma from SEER Program, between 1973–2015, were extracted. We analyzed the incidence rates by demographics and tumor characteristics, followed by analysis of its impact on survival. Results. The incidence of AA increased initially by 4.03% yearly from 1973 to 1985 but had a modest decline of 0.32% annually thereafter. The mean age for diagnosis of AA was 68.12 ± 14.02 years. Males outnumbered females by 54.8 to 45.2%. Tumors were mostly localized on presentation (44.4%) and moderately differentiated (41.1%). Age generally correlated with poor overall cancer survival. However, young patients (age <40 years) also showed poor long-term survival. Patients with localized disease and well-differentiated tumors showed better survival outcomes. Surgical intervention improved survival significantly as compared to patients who did not (116.7 months vs 42.7 months, p<0.01). Conclusions. Anal canal adenocarcinoma demonstrated a poor bimodal cancer-free survival in both younger and older patient groups. Surgery significantly improves odds of survival and should be offered to patients amenable to intervention. |
url |
http://dx.doi.org/10.1155/2020/5139236 |
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