Postsynaptic and Presynaptic NMDARs Have Distinct Roles in Visual Circuit Development

Postsynaptic and Presynaptic NMDARs Have Distinct Roles in Visual Circuit Development

Summary: To study contributions of N-methyl-D-aspartate receptors (NMDARs) in presynaptic and postsynaptic neurons of the developing visual system, we microinject antisense Morpholino oligonucleotide (MO) against GluN1 into one cell of two-cell-stage Xenopus laevis embryos. The resulting bilateral s...

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Bibliographic Details
Main Authors: Philip Kesner, Anne Schohl, Elodie C. Warren, Fan Ma, Edward S. Ruthazer
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
Xenopus
visual system
whole-cell electrophysiology
receptive field
two-photon microscopy
synapse
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309360

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