Submandibular salivary gland involvement in granulomatosis with polyangiitis
Abstract Introduction Granulomatosis with polyangiitis (GPA) is one of the forms of small vessel vasculitis. It is a rare condition that needs a high degree of suspicion to reach the diagnosis. It is one of the causes of diffuse parenchymal lung disease, with a very wide differential diagnosis. It i...
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doaj-bd57b27271634f618b998171080f8bcf2021-01-24T12:46:18ZengSpringerOpenThe Egyptian Journal of Bronchology1687-84262314-85512020-01-0113578178510.4103/ejb.ejb_15_19Submandibular salivary gland involvement in granulomatosis with polyangiitisMohamed F. Abdelghany0Mohammad G. A. Khalaf1Department of Chest Diseases, Faculty of Medicine, Assiut University Hospital, Assiut UniversityDepartment of Chest Diseases, Faculty of Medicine, Assiut University Hospital, Assiut UniversityAbstract Introduction Granulomatosis with polyangiitis (GPA) is one of the forms of small vessel vasculitis. It is a rare condition that needs a high degree of suspicion to reach the diagnosis. It is one of the causes of diffuse parenchymal lung disease, with a very wide differential diagnosis. It is commonly misdiagnosed with malignant, granulomatous, and infectious lung diseases. Case presentation We report a case of a 31-year-old male who presented with productive cough, shortness of breath, hemoptysis, nasal obstruction, and epistaxis together with submandibular salivary gland swelling. Diagnosis of GPA was based on characteristic cavitary lung lesions, nasal and salivary gland involvement, pathological samples that revealed necrotizing granulomatous inflammation, characteristic positive Cytoplasmic- ANCA (C-ANCA), together with exclusion of malignancy and tuberculosis. Conclusion GPA is a rare condition. Salivary gland involvement should raise suspicion about GPA, in addition to other systemic manifestations.https://doi.org/10.4103/ejb.ejb_15_19ANCAgranulomatosis with polyangiitissalivary glandWegener’sgranulomatosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohamed F. Abdelghany Mohammad G. A. Khalaf |
spellingShingle |
Mohamed F. Abdelghany Mohammad G. A. Khalaf Submandibular salivary gland involvement in granulomatosis with polyangiitis The Egyptian Journal of Bronchology ANCA granulomatosis with polyangiitis salivary gland Wegener’s granulomatosis |
author_facet |
Mohamed F. Abdelghany Mohammad G. A. Khalaf |
author_sort |
Mohamed F. Abdelghany |
title |
Submandibular salivary gland involvement in granulomatosis with polyangiitis |
title_short |
Submandibular salivary gland involvement in granulomatosis with polyangiitis |
title_full |
Submandibular salivary gland involvement in granulomatosis with polyangiitis |
title_fullStr |
Submandibular salivary gland involvement in granulomatosis with polyangiitis |
title_full_unstemmed |
Submandibular salivary gland involvement in granulomatosis with polyangiitis |
title_sort |
submandibular salivary gland involvement in granulomatosis with polyangiitis |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Bronchology |
issn |
1687-8426 2314-8551 |
publishDate |
2020-01-01 |
description |
Abstract Introduction Granulomatosis with polyangiitis (GPA) is one of the forms of small vessel vasculitis. It is a rare condition that needs a high degree of suspicion to reach the diagnosis. It is one of the causes of diffuse parenchymal lung disease, with a very wide differential diagnosis. It is commonly misdiagnosed with malignant, granulomatous, and infectious lung diseases. Case presentation We report a case of a 31-year-old male who presented with productive cough, shortness of breath, hemoptysis, nasal obstruction, and epistaxis together with submandibular salivary gland swelling. Diagnosis of GPA was based on characteristic cavitary lung lesions, nasal and salivary gland involvement, pathological samples that revealed necrotizing granulomatous inflammation, characteristic positive Cytoplasmic- ANCA (C-ANCA), together with exclusion of malignancy and tuberculosis. Conclusion GPA is a rare condition. Salivary gland involvement should raise suspicion about GPA, in addition to other systemic manifestations. |
topic |
ANCA granulomatosis with polyangiitis salivary gland Wegener’s granulomatosis |
url |
https://doi.org/10.4103/ejb.ejb_15_19 |
work_keys_str_mv |
AT mohamedfabdelghany submandibularsalivaryglandinvolvementingranulomatosiswithpolyangiitis AT mohammadgakhalaf submandibularsalivaryglandinvolvementingranulomatosiswithpolyangiitis |
_version_ |
1724325495710941184 |