Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice
Advances in big data analytics have created an opportunity for a step change in unraveling mechanisms underlying the development of complex diseases such as asthma, providing valuable insights that drive better diagnostic decision-making in clinical practice, and opening up paths to individualized t...
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doaj-bd58032bb70d42f19bb7cc7770678ada2020-11-24T22:19:34ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602018-09-01610.3389/fped.2018.00258406589Classification of Pediatric Asthma: From Phenotype Discovery to Clinical PracticeCeyda Oksel0Sadia Haider1Sara Fontanella2Clement Frainay3Clement Frainay4Adnan Custovic5Section of Paediatrics, Department of Medicine, Imperial College London, London, United KingdomSection of Paediatrics, Department of Medicine, Imperial College London, London, United KingdomSection of Paediatrics, Department of Medicine, Imperial College London, London, United KingdomDepartment of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, United KingdomINRA, UMR1331, Toxalim, Research Centre in Food Toxicology, Toulouse, FranceSection of Paediatrics, Department of Medicine, Imperial College London, London, United KingdomAdvances in big data analytics have created an opportunity for a step change in unraveling mechanisms underlying the development of complex diseases such as asthma, providing valuable insights that drive better diagnostic decision-making in clinical practice, and opening up paths to individualized treatment plans. However, translating findings from data-driven analyses into meaningful insights and actionable solutions requires approaches and tools which move beyond mining and patterning longitudinal data. The purpose of this review is to summarize recent advances in phenotyping of asthma, to discuss key hurdles currently hampering the translation of phenotypic variation into mechanistic insights and clinical setting, and to suggest potential solutions that may address these limitations and accelerate moving discoveries into practice. In order to advance the field of phenotypic discovery, greater focus should be placed on investigating the extent of within-phenotype variation. We advocate a more cautious modeling approach by “supervising” the findings to delineate more precisely the characteristics of the individual trajectories assigned to each phenotype. Furthermore, it is important to employ different methods within a study to compare the stability of derived phenotypes, and to assess the immutability of individual assignments to phenotypes. If we are to make a step change toward precision (stratified or personalized) medicine and capitalize on the available big data assets, we have to develop genuine cross-disciplinary collaborations, wherein data scientists who turn data into information using algorithms and machine learning, team up with medical professionals who provide deep insights on specific subjects from a clinical perspective.https://www.frontiersin.org/article/10.3389/fped.2018.00258/fullasthmaphenotypesdisease progressionmachine learninglongitudinal databig data |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ceyda Oksel Sadia Haider Sara Fontanella Clement Frainay Clement Frainay Adnan Custovic |
spellingShingle |
Ceyda Oksel Sadia Haider Sara Fontanella Clement Frainay Clement Frainay Adnan Custovic Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice Frontiers in Pediatrics asthma phenotypes disease progression machine learning longitudinal data big data |
author_facet |
Ceyda Oksel Sadia Haider Sara Fontanella Clement Frainay Clement Frainay Adnan Custovic |
author_sort |
Ceyda Oksel |
title |
Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice |
title_short |
Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice |
title_full |
Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice |
title_fullStr |
Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice |
title_full_unstemmed |
Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice |
title_sort |
classification of pediatric asthma: from phenotype discovery to clinical practice |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pediatrics |
issn |
2296-2360 |
publishDate |
2018-09-01 |
description |
Advances in big data analytics have created an opportunity for a step change in unraveling mechanisms underlying the development of complex diseases such as asthma, providing valuable insights that drive better diagnostic decision-making in clinical practice, and opening up paths to individualized treatment plans. However, translating findings from data-driven analyses into meaningful insights and actionable solutions requires approaches and tools which move beyond mining and patterning longitudinal data. The purpose of this review is to summarize recent advances in phenotyping of asthma, to discuss key hurdles currently hampering the translation of phenotypic variation into mechanistic insights and clinical setting, and to suggest potential solutions that may address these limitations and accelerate moving discoveries into practice. In order to advance the field of phenotypic discovery, greater focus should be placed on investigating the extent of within-phenotype variation. We advocate a more cautious modeling approach by “supervising” the findings to delineate more precisely the characteristics of the individual trajectories assigned to each phenotype. Furthermore, it is important to employ different methods within a study to compare the stability of derived phenotypes, and to assess the immutability of individual assignments to phenotypes. If we are to make a step change toward precision (stratified or personalized) medicine and capitalize on the available big data assets, we have to develop genuine cross-disciplinary collaborations, wherein data scientists who turn data into information using algorithms and machine learning, team up with medical professionals who provide deep insights on specific subjects from a clinical perspective. |
topic |
asthma phenotypes disease progression machine learning longitudinal data big data |
url |
https://www.frontiersin.org/article/10.3389/fped.2018.00258/full |
work_keys_str_mv |
AT ceydaoksel classificationofpediatricasthmafromphenotypediscoverytoclinicalpractice AT sadiahaider classificationofpediatricasthmafromphenotypediscoverytoclinicalpractice AT sarafontanella classificationofpediatricasthmafromphenotypediscoverytoclinicalpractice AT clementfrainay classificationofpediatricasthmafromphenotypediscoverytoclinicalpractice AT clementfrainay classificationofpediatricasthmafromphenotypediscoverytoclinicalpractice AT adnancustovic classificationofpediatricasthmafromphenotypediscoverytoclinicalpractice |
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