Protein Interaction and Na/K-ATPase-Mediated Signal Transduction
The Na/K-ATPase (NKA), or Na pump, is a member of the P-type ATPase superfamily. In addition to pumping ions across cell membrane, it is engaged in assembly of multiple protein complexes in the plasma membrane. This assembly allows NKA to perform many non-pumping functions including signal transduct...
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MDPI AG
2017-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/22/6/990 |
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doaj-bd5817e8f54e42418ed64049293b13012020-11-24T22:18:48ZengMDPI AGMolecules1420-30492017-06-0122699010.3390/molecules22060990molecules22060990Protein Interaction and Na/K-ATPase-Mediated Signal TransductionXiaoyu Cui0Zijian Xie1Marshall Institute for Interdisciplinary Research, Marshall University, Huntington, WV 25703, USAMarshall Institute for Interdisciplinary Research, Marshall University, Huntington, WV 25703, USAThe Na/K-ATPase (NKA), or Na pump, is a member of the P-type ATPase superfamily. In addition to pumping ions across cell membrane, it is engaged in assembly of multiple protein complexes in the plasma membrane. This assembly allows NKA to perform many non-pumping functions including signal transduction that are important for animal physiology and disease progression. This article will focus on the role of protein interaction in NKA-mediated signal transduction, and its potential utility as target for developing new therapeutics.http://www.mdpi.com/1420-3049/22/6/990Na/K-ATPaseSrcsignal transductioncardiotonic steroidsdrug target |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xiaoyu Cui Zijian Xie |
| spellingShingle |
Xiaoyu Cui Zijian Xie Protein Interaction and Na/K-ATPase-Mediated Signal Transduction Molecules Na/K-ATPase Src signal transduction cardiotonic steroids drug target |
| author_facet |
Xiaoyu Cui Zijian Xie |
| author_sort |
Xiaoyu Cui |
| title |
Protein Interaction and Na/K-ATPase-Mediated Signal Transduction |
| title_short |
Protein Interaction and Na/K-ATPase-Mediated Signal Transduction |
| title_full |
Protein Interaction and Na/K-ATPase-Mediated Signal Transduction |
| title_fullStr |
Protein Interaction and Na/K-ATPase-Mediated Signal Transduction |
| title_full_unstemmed |
Protein Interaction and Na/K-ATPase-Mediated Signal Transduction |
| title_sort |
protein interaction and na/k-atpase-mediated signal transduction |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2017-06-01 |
| description |
The Na/K-ATPase (NKA), or Na pump, is a member of the P-type ATPase superfamily. In addition to pumping ions across cell membrane, it is engaged in assembly of multiple protein complexes in the plasma membrane. This assembly allows NKA to perform many non-pumping functions including signal transduction that are important for animal physiology and disease progression. This article will focus on the role of protein interaction in NKA-mediated signal transduction, and its potential utility as target for developing new therapeutics. |
| topic |
Na/K-ATPase Src signal transduction cardiotonic steroids drug target |
| url |
http://www.mdpi.com/1420-3049/22/6/990 |
| work_keys_str_mv |
AT xiaoyucui proteininteractionandnakatpasemediatedsignaltransduction AT zijianxie proteininteractionandnakatpasemediatedsignaltransduction |
| _version_ |
1725781524918304768 |