Doxycycline rescues recognition memory and circadian motor rhythmicity but does not prevent terminal disease in fatal familial insomnia mice

Doxycycline rescues recognition memory and circadian motor rhythmicity but does not prevent terminal disease in fatal familial insomnia mice

Fatal familial insomnia (FFI) is a dominantly inherited prion disease linked to the D178N mutation in the gene encoding the prion protein (PrP). Symptoms, including insomnia, memory loss and motor abnormalities, appear around 50 years of age, leading to death within two years. No treatment is availa...

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Bibliographic Details
Main Authors: Giada Lavigna, Antonio Masone, Ihssane Bouybayoune, Ilaria Bertani, Jacopo Lucchetti, Marco Gobbi, Luca Porcu, Stefano Zordan, Mara Rigamonti, Luca Imeri, Elena Restelli, Roberto Chiesa
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Neurobiology of Disease
Subjects:
Genetic prion disease
Prion protein
PrP
Protein misfolding
Transgenic mice
Pharmacological therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121002047

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